Artery Research

Volume 4, Issue 4, December 2010, Pages 178 - 178

P10.10 EFFECT OF THE TREATMENT OF RHEUMATOID ARTHRITIS WITH ANTI-TNF-A INFLIXIMAB ON ARTERIAL WALL STIFFNESS PARAMETERS

Authors
A. Cypiene1, 2, A. Laucevicius1, 2, J. Dadoniene2, A. Venalis2, Z. Petrulioniene1, L. Ryliskyte1, M. Kovaite1
1Centre of Cardiology and Angiology Vilnius University Hospital Santariškiu Klinikos, Vilnius, Lithuania
2State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.113How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease, which may lead to arterial dysfunction. Treatment with anti-TNF-α infliximab can influence not only inflammation, disease activity, but can also greatly impact arterial wall function.

Aim of the study was to assess whether aortic augmentation index (AIx) and regional carotid-radial pulse wave velocity (PWV) were altered in RA patients treated with infliximab.

Methods: We examined 75 RA patients (age 42.03±10.69 years) with high disease activity (DAS28 5.40±0.93), 16 of them were treated with infliximab. AIx and PWV were assessed non-invasively by applanation tonometry (Sphygmocor v.7.01, AtCor Medical).

Results: By multiple regression analysis we have found that carotid-radial PWV depends only on mean blood pressure (MBP) and infliximab therapy. To test the influence of infliximab on arterial wall parameters, binary variable indicating the intake of infliximab was added to the list of independent predictors. The same forward analysis was applied after that. It has been established that infliximab reduced the values of PWV as compare with patients not treated with infliximab (7.69±0.69 vs. 8.61±1.02; p=0.001). However, no similar trend was observed for AIx (18.38±12.48 vs. 24.56±11.44; p=0.094). The estimated regression coefficient have implied that given fixed MBP, the mean PWV can be reduced approximately to 0.886 m/s in patients treated with infliximab.

Conclusions: The treatment with anti-TNF-α infliximab can influence the conduit arteries. Carotid-radial PWV may serve as a good marker to decide upon infliximab.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
178 - 178
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.113How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - A. Cypiene
AU  - A. Laucevicius
AU  - J. Dadoniene
AU  - A. Venalis
AU  - Z. Petrulioniene
AU  - L. Ryliskyte
AU  - M. Kovaite
PY  - 2010
DA  - 2010/12/02
TI  - P10.10 EFFECT OF THE TREATMENT OF RHEUMATOID ARTHRITIS WITH ANTI-TNF-A INFLIXIMAB ON ARTERIAL WALL STIFFNESS PARAMETERS
JO  - Artery Research
SP  - 178
EP  - 178
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.113
DO  - 10.1016/j.artres.2010.10.113
ID  - Cypiene2010
ER  -