P2.05 ARTERIAL WALL FUNCTION IN PATIENTS WITH CORONARY HEART DISEASE AND DYSLIPIDEMIA, COMPARATIVE EFFICACY OF EZETIMIBE, STATINS AND THEIR COMBINATION

M.I. Tripoten; O.A. Pogorelova; M.Y. Zubareva; V.V. Kukharchuk; A.N. Rogoza; A.V. Susekov; T.V. Balakhonova

doi:10.1016/j.artres.2010.10.038

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Volume 4, Issue 4, December 2010, Pages 157 - 158

P2.05 ARTERIAL WALL FUNCTION IN PATIENTS WITH CORONARY HEART DISEASE AND DYSLIPIDEMIA, COMPARATIVE EFFICACY OF EZETIMIBE, STATINS AND THEIR COMBINATION

Authors

M.I. Tripoten, O.A. Pogorelova, M.Y. Zubareva, V.V. Kukharchuk, A.N. Rogoza, A.V. Susekov, T.V. Balakhonova

Cardiology Research Center, Moscow, Russian Federation

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.038 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Purpose: The aim of this study was to compare efficacy of treatment by ezetimibe (EZ), starting doses of statins and their combination on lipids and arterial wall function in patients with documented coronary heart disease and dyslipidemia in 24 weeks’ randomized controlled trial.

Methods: 60 patients (32 men, 28 women, age 61±8) were randomized into 4 groups with equal number of pts (n=15). In each group pts received drugs as monotherapy: EZ 10mg, simvastatin 10mg, atorvastatin 10mg, rosuvastatin 10mg. After 12 weeks, if LDL-cholesterol (LDL-C) level was more than 2,5mmol/l in statins monotherapy treatment, EZ 10 mg was added. LDL-C, stiffness parameter β, compliance (CC) and distensibility (DC) coefficients were determined by high-resolution ultrasound before and after 12 and 24 weeks of treatment. For analysis pts was reform in 3 groups: 1 - pts taken only EZ (n=15), 2 - pts taken only statins (n=19), 3 - pts taken combination statins and EZ (n=24).

Results: After 12 and 24 weeks of treatment the level of LDL-C significantly decreased in all groups. Stiffness, CC and DC also was significantly changed (in table below, % changes from baseline).

Conclusions: Arterial stiffness, compliance and distensibility are significantly changed after 12 and 24 weeks of treatment in all groups. We did not find significantly intergroup differences of theses parameters.

EZ			Statins		Statins and EZ

weeks	12	24	12	24	12	24
LDL-C, %	− 16,4^{^}	− 11,2^°	− 34,7^*	− 43^*	− 25^°	− 45,7^{^}
β, %	− 20^*	− 32,5^*	− 22,6^*	− 29^*	− 11,4^*	− 20^*
CC, %	+10 n/s	+ 26^°	+5,5 n/s	+ 18^°	+ 5,6 n/s	+ 25^°
DC, %	+ 21^*	+ 41^*	+ 13^{^}	+ 27^*	+ 11^°	+ 20^°

*

- p<0,001,

^

- p<0,01,

°

- p<0,05, n/s - no significantly.

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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 157 - 158
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.038 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - M.I. Tripoten
AU  - O.A. Pogorelova
AU  - M.Y. Zubareva
AU  - V.V. Kukharchuk
AU  - A.N. Rogoza
AU  - A.V. Susekov
AU  - T.V. Balakhonova
PY  - 2010
DA  - 2010/12/02
TI  - P2.05 ARTERIAL WALL FUNCTION IN PATIENTS WITH CORONARY HEART DISEASE AND DYSLIPIDEMIA, COMPARATIVE EFFICACY OF EZETIMIBE, STATINS AND THEIR COMBINATION
JO  - Artery Research
SP  - 157
EP  - 158
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.038
DO  - 10.1016/j.artres.2010.10.038
ID  - Tripoten2010
ER  -

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