Artery Research

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Volume 4, Issue 4, December 2010, Pages 149 - 149

5.6 CENTRAL BUT NOT PERIPHERAL FAT MASS IS ASSOCIATED WITH BLOOD PRESSURE COMPONENTS

Authors
S.C. van Dijk1, *, N. van der Velde1, A.H. van den Meiracker2, F.U.S. Mattace-Raso1, T.J.M. van der Cammen1
1Erasmus Medical Center, Section of Geriatric Medicine, Rotterdam, Netherlands
2Erasmus Medical Center, Section of Vascular Medicine, Rotterdam, Netherlands
*Corresponding author.
Corresponding Author
S.C. van Dijk
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.177How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: Both obesity and arterial stiffness are associated with cardiovascular disease. In the present study we investigated the possible associations between fat mass, measured at different locations, and measures of arterial stiffness in a geriatric outpatient’s population.

Methods: Cross-sectional study. Fat mass was measured at different locations with a dual-energy X-ray absorptiometry (DEXA). Blood pressure was measured with Dynamap®, central blood pressure and augmentation index were calculated with Sphygmocor®. Associations were tested by regression analysis.

Results: 216 subjects were included. Mean age was 77.3 years. Central fat mass was associated with pulse pressure (PP) [0.579 (95CI% 0.177;0.981)], systolic blood pressure (SPB) [0.581 (95CI% 0.196;0.966)] and negatively with diastolic blood pressure (DBP) [−0.215 (95CI% −0.365;−0.064)], whereas peripheral fat mass was not (table 1). No association was found between measures of obesity and the AIx.

SBP β (95% CI) DBP β (95% CI) PP β (95% CI) AIx β (95% CI)
FM arms 0.025 (−0.052;0.101) −0.006 (−0.036;0.024) 0.024 (−0.056;0.104) −0.017 (−0.056;0.023)
FM legs 0.307 (−0.124;0.738) −0.132(−0.300;0.036) 0.395 (−0.052;0.843) 0.139 (−0.083;0.360)
FM trunk 0.581 (0.196;0.966) −0.215 (−0.365;−0.064) 0.579 (0.177;0.981) 0.148 (−0.053;0.349)

Model is adjusted for age, gender, MAP, HR and BMI.

Table 1

Associations between central and peripheral fat mass percentages (FM) and blood pressure components.

Conclusion: In the elderly, central but not peripheral fat mass is associated with blood pressure levels. The present study suggests the pathophysiological role of central fat mass in determining blood pressure levels.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
149 - 149
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.177How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - S.C. van Dijk
AU  - N. van der Velde
AU  - A.H. van den Meiracker
AU  - F.U.S. Mattace-Raso
AU  - T.J.M. van der Cammen
PY  - 2010
DA  - 2010/12/02
TI  - 5.6 CENTRAL BUT NOT PERIPHERAL FAT MASS IS ASSOCIATED WITH BLOOD PRESSURE COMPONENTS
JO  - Artery Research
SP  - 149
EP  - 149
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.177
DO  - 10.1016/j.artres.2010.10.177
ID  - vanDijk2010
ER  -