P3.12 BLOOD PRESSURE CHANGES IN ASSOCIATION WITH PERSONAL BLACK CARBON EXPOSURE ARE NOT MEDIATED THROUGH MICROCIRCULATORY RESPONSES

T. Louwies; P. De Boever; B. Cox; J. Penders; L. Panis; T. Nawrot

doi:10.1016/j.artres.2014.09.123

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Volume 8, Issue 4, December 2014, Pages 139 - 139

P3.12 BLOOD PRESSURE CHANGES IN ASSOCIATION WITH PERSONAL BLACK CARBON EXPOSURE ARE NOT MEDIATED THROUGH MICROCIRCULATORY RESPONSES

Authors

T. Louwies^a^{, b}^{, d}, P. De Boever^a^{, b}^{, d}, B. Cox^b^{, d}, J. Penders^c^{, d}, L. Panis^a^{, b}^{, d}, T. Nawrot^b^{, d}

^aFlemish Institute for Technological Research (VITO), Mol, Belgium

^bHasselt University, Diepenbeek, Belgium

^cZiekenhuis Oost-Limburg, Genk, Belgium

^dLeuven University (KU Leuven), Leuven, Belgium

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.123 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Exposure to ambient particulate matter and elevated blood pressure are risk factors for cardiovascular morbidity and mortality. Microvascular changes might be an important pathway in the association between air pollution and blood pressure. The objective of the study was to evaluate the role of the retinal microcirculation in the association between black carbon exposure and blood pressure.

A total of 56 healthy adults were provided with a μ-aethalometer for one week to measure personal exposure to black carbon. Blood pressure and retinal microvasculature were measured on average on four different days (range: 2–4) during this week.

Mean black carbon exposure was 866 ± 425 ng/m³ and ranged from 201 ng/m³ to 2415 ng/m³. An interquartile range increase (313 ng/m³) in black carbon exposure was associated with a 2.80 mm Hg (95% CI: 1.12 to 4.49, p<0.01) increase in systolic blood pressure and a 2.48 mm Hg (95% CI: 1.21 to 3.74, p<0.001) increase in diastolic blood pressure. These associations were independent of individual characteristics and time varying factors. Mediation analysis failed to reveal an effect of retinal microvasculature in the association between blood pressure and black carbon.

In conclusion, we found a positive association between blood pressure and personal black carbon exposure in healthy adults. This finding adds evidence to the association between black carbon exposure and cardiovascular health effects, with elevated blood pressure as a plausible intermediate effector. Our results suggest that the association between a person’s usual blood pressure and black carbon exposure operates independent of the microcirculation.

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Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 139 - 139
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.123 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - T. Louwies
AU  - P. De Boever
AU  - B. Cox
AU  - J. Penders
AU  - L. Panis
AU  - T. Nawrot
PY  - 2014
DA  - 2014/11/04
TI  - P3.12 BLOOD PRESSURE CHANGES IN ASSOCIATION WITH PERSONAL BLACK CARBON EXPOSURE ARE NOT MEDIATED THROUGH MICROCIRCULATORY RESPONSES
JO  - Artery Research
SP  - 139
EP  - 139
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.123
DO  - 10.1016/j.artres.2014.09.123
ID  - Louwies2014
ER  -

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