P7.10 RENAL FUNCTION DOES NOT MODIFY PREDICTIVE VALUE OF CENTRAL PULSE PRESSURE AND PULSATILITY IN PATIENTS WITH CAD
- DOI
- 10.1016/j.artres.2011.10.117How to use a DOI?
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Background: The differences between central and peripheral blood pressure (BP) values have been known for decades. Although the predictive value of central BP in coronary patients with impaired renal function has not been studied so far. Therefore, the aim of the study was to assess the influence of renal function on the predictive value of ascending aortic pulse pressure (PP) and pulsatility (the ratio of PP to mean BP) in patients with coronary artery disease.
Methods: The study group consisted of 755 patients (214 women and 545 men; mean age: 57.7±10.0 years) with preserved left ventricular function (EF>40%) undergoing coronary angiography. Demographic and clinical information as well as invasive ascending aortic BP were obtained at baseline. The follow-up was 53.1±18.7 months. The primary end point was: cardiovascular death, myocardial infarction, stroke, cardiac arrest or myocardial revascularization. The Cox proportional hazard regression analysis was used to assess the relation between BP and primary end point.
Results: The primary end point occurred in 152 (20.1%) patients whereas CV death, myocardial infarction (MI) or stroke in 79 (10.5%) subjects. Both ascending aortic PP (increase per 10 mmHg: HR 1.12 [95% CI 1.01–1.24]) and pulsatility (increase per 0.1: 1.18 [1.04–1.34]) predicted the risk of primary end point as well as of CV death, MI, or stroke (1.14 [1.00–1.33] and 1.30 [1.10–1.54], resp.). HRs according to the stage of chronic renal disease are presented in the table.
Conclusion: Renal function does not modify predictive value of central pulse pressure and pulsatility in patients with CAD.
| GFR<60 ml/min/1.73m2 | GFR 60–90 ml/min/1.73m2 | GFR≥90 ml/min/1.73m2 | P for interaction | |
|---|---|---|---|---|
| Primary end point | ||||
| Central PP | 1.09 | 1.19 | 1.09 | NS |
| Central pulsatility | 1.07 | 1.30 | 1.12 | NS |
| CV death, MI or stroke | ||||
| Central PP | 1.11 | 1.11 | 1.24 | NS |
| Central pulsatility | 1.37 | 1.32 | 1.32 | NS |
Values are hazard ratios for 10 mmHg increase in PP and 0.1 in pulsatility
Cite this article
TY - JOUR AU - P. Jankowski AU - A. Bednarek AU - M. Kloch-Badełek AU - J. Wiliński AU - L. Bryniarski AU - D. Dudek AU - D. Czarnecka AU - K. Kawecka-Jaszcz PY - 2011 DA - 2011/11/29 TI - P7.10 RENAL FUNCTION DOES NOT MODIFY PREDICTIVE VALUE OF CENTRAL PULSE PRESSURE AND PULSATILITY IN PATIENTS WITH CAD JO - Artery Research SP - 181 EP - 181 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.117 DO - 10.1016/j.artres.2011.10.117 ID - Jankowski2011 ER -