Assessment of peripheral vascular function with photoplethysmographic pulse amplitude

Tatiana Kuznetsova; Gregory Szczesny; Lutgarde Thijs; Dominique Jozeau; Jan D’hooge; Jan A. Staessen

doi:10.1016/j.artres.2011.03.001

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Volume 5, Issue 2, June 2011, Pages 58 - 64

Assessment of peripheral vascular function with photoplethysmographic pulse amplitude

Authors

Tatiana Kuznetsova^a^{, *}, Gregory Szczesny^b, Lutgarde Thijs^a, Dominique Jozeau^b, Jan D’hooge^c, Jan A. Staessen^a

^aThe Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Campus Gasthuisberg, Herestraat 49, Box 702, B-3000 Leuven, Belgium

^bFLOMEDI Company, Brussels, Belgium

^cDivision of Cardiovascular Imaging and Dynamics, Department of Cardiovascular Disease, University of Leuven, Belgium

^*Corresponding author. E-mail address: tatiana.kouznetsova@med.kuleuven.be (T. Kuznetsova).

Corresponding Author

Tatiana Kuznetsova

Received 1 February 2011, Revised 24 February 2011, Accepted 1 March 2011, Available Online 6 April 2011.

DOI: 10.1016/j.artres.2011.03.001 How to use a DOI?
Keywords: Population; Vasodilation; Photoplethysmography; Endothelial function
Abstract: Background: Vasodilation of the peripheral arteries after reactive hyperaemia depends in part on the release of nitric oxide from endothelial cells. Previous studies mainly employed a fingertip tonometric device to derive pulse wave amplitude (PWA) and, therefore, measure PWA hyperaemic changes. Another approach to derive information about PWA is based on photoplethysmography (PPG). We sought to evaluate the correlates of digital PPG PWA hyperaemic responses as a measure of peripheral vascular function.

Methods: Using a fingertip PPG device, we measured digital PWA in 63 subjects enrolled in a population study (55.5% women; mean age, 55 years; 58.7% hypertensive) at baseline and at 30-s intervals for 4 min during reactive hyperaemia induced by a 5-min forearm cuff occlusion. We performed stepwise regression to identify correlates of the hyperaemic response ratio for each 30-s interval after cuff deflation.

Results: With age forced into the models, the explained variance for the PPG PWA ratio totalled from 17.1% at the 210–240-s time interval to 31.3% at 30–60-s time interval. The hyperaemic response at each 30-s interval was significantly higher in women compared to men (P < 0.001). The PPG PWA changes at 0–60-s intervals decreased with higher blood pressure (BP) (P < 0.03). These associations with sex and systolic BP were mutually independent.

Conclusions: Our study described in a population sample the determinants of PPG PWA hyperaemic changes. We demonstrated that measurement of the hyperaemic response by PPG might be a useful tool in the detection of endothelial dysfunction associated with higher BP and male gender.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 5 - 2
Pages: 58 - 64
Publication Date: 2011/04/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.03.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Tatiana Kuznetsova
AU  - Gregory Szczesny
AU  - Lutgarde Thijs
AU  - Dominique Jozeau
AU  - Jan D’hooge
AU  - Jan A. Staessen
PY  - 2011
DA  - 2011/04/06
TI  - Assessment of peripheral vascular function with photoplethysmographic pulse amplitude
JO  - Artery Research
SP  - 58
EP  - 64
VL  - 5
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.03.001
DO  - 10.1016/j.artres.2011.03.001
ID  - Kuznetsova2011
ER  -

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