Aortic pulse wave velocity measured by pulse wave imaging (PWI): A comparison with applanation tonometry

Jonathan Vappou; Jianwen Luo; Kazue Okajima; Marco Di Tullio; Elisa Konofagou

doi:10.1016/j.artres.2011.03.002

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Volume 5, Issue 2, June 2011, Pages 65 - 71

Aortic pulse wave velocity measured by pulse wave imaging (PWI): A comparison with applanation tonometry

Authors

Jonathan Vappou^a^{, 1}, Jianwen Luo^a, Kazue Okajima^b, Marco Di Tullio^b, Elisa Konofagou^a^{, *}

^aDepartment of Biomedical Engineering, Columbia University, New York, NY, USA

^bDepartment of Medicine, Division of Cardiology, Columbia University, New York, NY, USA

¹

Present address: LSIIT, UMR 7005 CNRS-Strasbourg University, France.

^*Corresponding author. Tel.: +1 212 854 9661, 212 342 0863; fax: +1 212 342 5773. E-mail address: ek2191@columbia.edu (E. Konofagou).

Corresponding Author

Elisa Konofagou

Received 11 January 2011, Revised 25 February 2011, Accepted 3 March 2011, Available Online 3 April 2011.

DOI: 10.1016/j.artres.2011.03.002 How to use a DOI?
Keywords: Arterial stiffness; Pulse wave velocity; Ultrasound imaging; Applanation tonometry
Abstract: Background: Arterial stiffness is a well-established indicator of cardiovascular disease outcome. Pulse Wave Velocity (PWV) is a surrogate for arterial stiffness that is measured either globally using carotid-to-femoral applanation tonometry or locally using biomedical imaging methods. Pulse Wave Imaging (PWI) is an ultrasound-based method for both qualitative visualization of the pulse wave propagation and quantitative estimation of arterial stiffness. The objective of this study is to assess the PWI performance in PWV estimation by comparing local abdominal aortic PWV values obtained by PWI to the carotid-femoral PWV measured by applanation tonometry.

Methods: A total of 18 subjects (age 18–66, 32.5 ± 14.5) with no history of cardiovascular disease were consecutively tested by both PWI and tonometry.

Results: The correlation coefficient r between values estimated with the two methods was found to be equal to 0.68. A linear regression yielded PWV_PWI = 1.02^* PWV_tonometry +0.15. Tukey mean-difference plots indicated that PWV_PWI was significantly lower than PWV_tonometry (−0.3 m/s) at lower PWV values (PWV ≤ 7 m/s), whereas PWV_PWI was significantly higher (+1.4 m/s) than PWV_tonometry at higher PWV values (PWV > 7 m/s).

Conclusions: Despite the regional nature of the PWV_PWI measurements, as opposed to the global PWV_tonometry measurements, abdominal PWV_PWI and carotid-femoral PWV_tonometry values were found to be similar, with an average bias equal to 0.25 m/s. Such a bias and its variation with PWV may be partially explained by both physiological variations of PWV along the arterial tree and by the increasing uncertainty of the PWV estimate by PWI as PWV increases.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 5 - 2
Pages: 65 - 71
Publication Date: 2011/04/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.03.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Jonathan Vappou
AU  - Jianwen Luo
AU  - Kazue Okajima
AU  - Marco Di Tullio
AU  - Elisa Konofagou
PY  - 2011
DA  - 2011/04/03
TI  - Aortic pulse wave velocity measured by pulse wave imaging (PWI): A comparison with applanation tonometry
JO  - Artery Research
SP  - 65
EP  - 71
VL  - 5
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.03.002
DO  - 10.1016/j.artres.2011.03.002
ID  - Vappou2011
ER  -

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