Artery Research

Volume 8, Issue 1, March 2014, Pages 16 - 23

Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE−/− mice

Authors
Bram Tracheta, c, *, M. Renardd, C. Van der Donckte, S. Deleyeb, g, J. Bolsa, G.R.Y. De Meyere, S. Staelensb, g, B.L. Loeysd, f, P. Segersa
aIBiTech – bioMMeda, Ghent University – IMinds, Belgium
bIBiTech-Medisip, Ghent University-IMinds, Belgium
cLHTC, EPFL, Lausanne, Switzerland
dCenter for Medical Genetics, Ghent University, Belgium
eDivision of Physiopharmacology, Antwerp University, Belgium
fCentre of Medical Genetics, Antwerp University, Belgium
gMolecular Imaging Center, Antwerp University, Belgium
*Corresponding author. IBiTech – bioMMeda, Ghent University – IMinds, De Pintelaan 185B, Ghent, Belgium. E-mail address: bram.trachet@ugent.be (B. Trachet).
Corresponding Author
Bram Trachet
Received 22 November 2013, Accepted 2 January 2014, Available Online 1 February 2014.
DOI
https://doi.org/10.1016/j.artres.2014.01.001How to use a DOI?
Keywords
Small animal imaging, In vivo micro-CT, High-frequency ultrasound, PET, Angiotensin II, Ascending aortic aneurysm, Abdominal aortic aneurysm, Mice
Abstract

Purpose: To explore new imaging techniques to elucidate some of the differences between both abdominal and ascending aortic aneurysms in the angiotensin II mouse model.

Procedures: Angiotensin II-infusing pumps were implanted in male ApoE−/− mice (n = 10). In vivo micro-CT, ultrasound and Positron emission tomography (PET) were used to follow up on aneurysm formation.

Results: We observed that the ascending aortic aneurysm gradually increased in size over the course of 49 days, while the abdominal aneurysm appeared much more suddenly in between scan times, or in some cases was not detectable at all on micro-CT. Diastolic backflow was detected from day 7 on in the ascending aorta, but not in the abdominal aorta of animals developing an aneurysm at the respective location. Finally PET 18F-FDG uptake was increased in both the ascending and the abdominal aneurysmatic aorta at day 14, but not at day 7.

Conclusions: Novel imaging techniques should be explored in-depth to come to a better understanding of the difference in morphology and hemodynamics between ascending and abdominal aneurysms in angiotensin II-infused ApoE−/− mice.

Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
8 - 1
Pages
16 - 23
Publication Date
2014/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2014.01.001How to use a DOI?
Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Bram Trachet
AU  - M. Renard
AU  - C. Van der Donckt
AU  - S. Deleye
AU  - J. Bols
AU  - G.R.Y. De Meyer
AU  - S. Staelens
AU  - B.L. Loeys
AU  - P. Segers
PY  - 2014
DA  - 2014/02
TI  - Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE−/− mice
JO  - Artery Research
SP  - 16
EP  - 23
VL  - 8
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.01.001
DO  - https://doi.org/10.1016/j.artres.2014.01.001
ID  - Trachet2014
ER  -