Hemodynamic investigation of intraluminal thrombus effect on the wall stress in a stented three-layered aortic aneurysm model under pulsatile flow

Mohammad Alagheband; Shahrokh Rahmani; Mansour Alizadeh; Alireza Karimi; Mahdi Navidbakhsh

doi:10.1016/j.artres.2015.01.002

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Volume 10, Issue C, June 2015, Pages 11 - 19

Hemodynamic investigation of intraluminal thrombus effect on the wall stress in a stented three-layered aortic aneurysm model under pulsatile flow

Authors

Mohammad Alagheband^a^{, b}, Shahrokh Rahmani^a^{, b}, Mansour Alizadeh^a^{, b}, Alireza Karimi^a^{, b}, Mahdi Navidbakhsh^a^{, b}^{, *}

^aSchool of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran

^bTissue Engineering and Biological Systems Research Laboratory, School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran

^*Corresponding author. School of Mechanical Engineering, Iran University of Science and Technology, Tehran 16846, Iran. Tel.: +98 21 77209027; fax: +98 21 73021585. E-mail address: mnavid@iust.ac.ir (M. Navidbakhsh).

Corresponding Author

Mahdi Navidbakhsh

Received 18 November 2014, Revised 14 January 2015, Accepted 16 January 2015, Available Online 11 February 2015.

DOI: 10.1016/j.artres.2015.01.002 How to use a DOI?
Keywords: Aneurysm; Stent; Intraluminal thrombus; Fluid-structure interaction; Numerical analysis
Abstract: Purpose: Aortic aneurysms occurs when the wall stress exceeds the strength of the vascular tissue. Intraluminal Thrombus (ILT) may absorb tension and reduce the aortic aneurysm wall stress. The purpose of this study is to test the hypothesis that the presence and growth of ILT alters the wall stress in a stented aneurysm.

Method: A virtual stented aneurysm model with ILT is created to study the flow and wall dynamics by means of Fluid-Structure Interaction (FSI) analysis. Wall stresses are determined by two-dimensional axisymmetric finite element analysis. Calculations are performed as thrombus elastic modulus increased from 0.1 to 2 MPa and calculations are repeated as thrombus depth is increased in 10% increment until thrombus fills the entire aneurysm cavity.

Results: The blood flow velocity, pressure, and maximum wall stresses are compared to the aforementioned models. The maximum stress reduction of 46% occurs at the time of peak flow and 28% at the time of peak pressure when thrombus elastic modulus increases from 0.1 to 2 MPa. In addition, as the thrombus depth increased from 10% to 100 %, the wall stress at the time of peak flow and peak pressure decreased almost 25% and 20%.

Conclusions: The findings of this study may have implications not only for understanding the wall stress in ILT but also for providing more detailed information about aortic aneurysm with intraluminal thrombus.
Copyright: © 2015 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 10 - C
Pages: 11 - 19
Publication Date: 2015/02/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.01.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Mohammad Alagheband
AU  - Shahrokh Rahmani
AU  - Mansour Alizadeh
AU  - Alireza Karimi
AU  - Mahdi Navidbakhsh
PY  - 2015
DA  - 2015/02/11
TI  - Hemodynamic investigation of intraluminal thrombus effect on the wall stress in a stented three-layered aortic aneurysm model under pulsatile flow
JO  - Artery Research
SP  - 11
EP  - 19
VL  - 10
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.01.002
DO  - 10.1016/j.artres.2015.01.002
ID  - Alagheband2015
ER  -

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