Artery Research

Volume 10, Issue C, June 2015, Pages 20 - 26

Vitamin E attenuates alcohol-induced aortic wall damage in rats

Authors
Leila Norouzia, Alireza Shirpoora, *, Mohammad-Hasan Khadem Ansarib, Behrouz Ilkhanizadehc
aDepartment of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
bDepartment of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
cDepartment of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
*Corresponding author. Tel.: +98 4412770698; fax: +98 4412780801. E-mail addresses: liliphysio@yahoo.com (L. Norouzi), ashirpoor@yahoo.com (A. Shirpoor), khademansari_mh@hotmail.com (M.-H.Khadem Ansari), ilkhanib@gmail.com (B. Ilkhanizadeh).
Corresponding Author
Alireza Shirpoor
Received 17 November 2014, Revised 25 January 2015, Accepted 27 January 2015, Available Online 14 February 2015.
DOI
10.1016/j.artres.2015.01.003How to use a DOI?
Keywords
Ethanol; Rat; Oxidative stress; Vascular; Vitamin E
Abstract

Background: In this study the effect of chronic ethanol consumption on vascular wall abnormality via oxidative stress was examined. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rat vascular wall.

Methods: Twenty-four male wistar rats were divided into three groups, namely, control, ethanol (4.5 g/kgBW intragastrically), and vitamin E treated ethanolic groups(VETE) (300 mg interagastrically).

Results: After 6 weeks treatment of rats, the results revealed that along with a significant increase VSMC proliferation and aorta wall thickness with the increase in the level of Ox-LDL, protein carbonyl, as well as decrease total antioxidant capacity in animal that received ethanol compared to the control group. Significant amelioration of aorta wall changes, along restoration of the elevated level of Ox-LDL, protein carbonyl, lipid profile, and decreased level of total antioxidant capacity to that of controls were found in vitamin E-treated animals.

Conclusions: These findings strongly support the idea that heavy and chronic ethanol consumption initiate atherosclerosis by oxidative stress, and that these effects can be alleviated by vitamin E as an antioxidant.

Copyright
© 2015 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
10 - C
Pages
20 - 26
Publication Date
2015/02/14
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.01.003How to use a DOI?
Copyright
© 2015 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Leila Norouzi
AU  - Alireza Shirpoor
AU  - Mohammad-Hasan Khadem Ansari
AU  - Behrouz Ilkhanizadeh
PY  - 2015
DA  - 2015/02/14
TI  - Vitamin E attenuates alcohol-induced aortic wall damage in rats
JO  - Artery Research
SP  - 20
EP  - 26
VL  - 10
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.01.003
DO  - 10.1016/j.artres.2015.01.003
ID  - Norouzi2015
ER  -