Optimality, cost minimization and the design of arterial networks
- https://doi.org/10.1016/j.artres.2015.01.001How to use a DOI?
- Circulation, Design, Optimality, Shear stress
The arterial circulation acts as a network to deliver nutrients and oxygen to cells. The design of the cardiovascular system is subject to a variety of constraints and costs. It has been postulated that the design of the arterial network might be understood in terms of the need to minimize competing ‘costs’ within the context of physical or material limits to the system. These designs can also be envisaged as being subservient to space filling or fractal considerations. The signalling mechanisms underlying these designs remain to be fully characterized although shear stress, wall tensile stress and metabolic stimuli are likely candidates. I will also review evidence that deviations from a minimal cost condition or optimal design may provide both a measure of disease severity and insights into the underlying disease mechanism.
- © 2015 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - JOUR AU - Alun D. Hughes PY - 2015 DA - 2015/02 TI - Optimality, cost minimization and the design of arterial networks JO - Artery Research SP - 1 EP - 10 VL - 10 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.01.001 DO - https://doi.org/10.1016/j.artres.2015.01.001 ID - Hughes2015 ER -