Artery Research

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Volume 19, Issue C, September 2017, Pages 18 - 23

Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms☆

Authors
T.T. van Sloten*
Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
☆

Review linked to Career Development Lecture, Artery Meeting, Copenhagen, 2016.

*Maastricht University Medical Centre, Department of Medicine, Prof. Debyelaan 25, 6229HX Maastricht, The Netherlands. Fax: +31 433875006. E-mail address: t.vansloten@maastrichtuniveristy.nl.
Corresponding Author
T.T. van Sloten
Received 6 November 2016, Revised 12 April 2017, Accepted 7 May 2017, Available Online 23 May 2017.
DOI
10.1016/j.artres.2017.05.002How to use a DOI?
Keywords
Arterial stiffness; Endothelial dysfunction; Cerebral small vessel disease; Dementia; Depression
Abstract

Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. Data were used of The Hoorn Study, The AGES-Reykjavik Study, The Maastricht Study and The SUVIMAX2 Study. In addition, we did two systematic reviews and an individual participant data meta-analysis.

Copyright
© 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
19 - C
Pages
18 - 23
Publication Date
2017/05/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.05.002How to use a DOI?
Copyright
© 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

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TY  - JOUR
AU  - T.T. van Sloten
PY  - 2017
DA  - 2017/05/23
TI  - Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms☆
JO  - Artery Research
SP  - 18
EP  - 23
VL  - 19
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.05.002
DO  - 10.1016/j.artres.2017.05.002
ID  - vanSloten2017
ER  -