Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population
- https://doi.org/10.1016/j.artres.2017.04.007How to use a DOI?
- Reproducibility study, Carotid artery, Intima-media thickness, Carotid plaques
Introduction: Common carotid artery (CCA) intima-media thickness (IMT), lumen diameter, and maximum plaque thickness were assessed on ultrasound images. The objective of the study was to evaluate the intra- and inter-reader reproducibility of the measurements following a standardised protocol.
Methods: Two readers performed the off-line measurements on B-mode ultrasound images of the distal CCA, in a randomly selected subset (n = 60) from a Flemish population cohort (FLEMENGHO). We calculated the coefficient of variation, the interclass correlation coefficient (ICC) and reproducibility according to the Bland–Altman method.
Results: The intra-reader bias for the measurements of left and right side CCA IMT were −0.003 ± 0.04 mm (p = 0.55) and 0.01 ± 0.04 mm (p = 0.03), respectively. The intra-reader bias of the lumen diameter was −0.04 ± 0.25 mm (p = 0.27) for the left and 0.02 ± 0.22 mm (p = 0.45) for the right side. The measurements for the maximum plaque thickness showed no intra-reader differences with bias 0.07 ± 0.2 mm (p = 0.26) for the left and −0.03 ± 0.2 mm (p = 0.55) for the right side. The inter-reader analysis showed good reproducibility for the left and right side CCA IMT with bias 0.004 ± 0.06 mm (p = 0.57) and −0.008 ± 0.05 mm (p = 0.19), respectively, but the lumen diameter measurements showed inter-reader differences, with bias 0.17 ± 0.27 mm (p < 0.0001) for the left and 0.10 ± 0.21 mm (p = 0.0006) for the right side. The inter-reader bias for the maximum plaque thickness were 0.07 ± 0.2 mm (p = 0.21) and −0.1 ± 0.4 mm (p = 0.26) for the left and right side, respectively.
Conclusion: The results demonstrated a reliable reproducibility of carotid wall structural measurements, allowing for an adequate further analysis of the entire population cohort.
- © 2017 The Authors. Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
- Open Access
- This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Cite this article
TY - JOUR AU - Ljupcho Efremov AU - Wen-Yi Yang AU - Lotte Jacobs AU - Lutgarde Thijs AU - Tatiana Kuznetsova AU - Harry A.J. Struijker-Boudier AU - Jan A. Staessen PY - 2017 DA - 2017/05 TI - Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population JO - Artery Research SP - 9 EP - 17 VL - 19 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2017.04.007 DO - https://doi.org/10.1016/j.artres.2017.04.007 ID - Efremov2017 ER -