Artery Research

Volume 23, Issue C, September 2018, Pages 32 - 38

Validity and reliability of carotid-toe pulse wave velocity as a measure of arterial stiffness in healthy individuals: Comparison to carotid-femoral pulse wave velocity

Authors
Stephen A. Klassen, Kylie S. Dempster, Daniele Chirico, Deborah D. O’Leary*
Faculty of Applied Health Sciences, Brock-Niagara Centre for Health and Well-Being, Brock University, St. Catharines, Ontario, Canada
*Corresponding author. Department of Health Sciences, Brock-Niagara Centre for Health and Well-Being, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada. Fax: +1 905 688 8954. E-mail address: doleary@brocku.ca (D.D. O’Leary).
Corresponding Author
Deborah D. O’Leary
Received 19 March 2018, Revised 4 July 2018, Accepted 14 July 2018, Available Online 28 July 2018.
DOI
https://doi.org/10.1016/j.artres.2018.07.001How to use a DOI?
Keywords
Arterial stiffness, Carotid-toe pulse wave velocity, Carotid-femoral pulse wave velocity, Validity, Reliability, Tonometry
Abstract

Purpose: The present investigation evaluated the validity and reliability of carotid-toe PWV (ctPWV) as a non-intrusive measure of systemic arterial stiffness in healthy young adults.

Methods: The Validity Trial examined the association and agreement between cfPWV and ctPWV in 33 adults (24 ± 2 years; 14 females), while the Reliability Trial assessed the variability in cfPWV and ctPWV in 13 adults (22 ± 2 years; 5 females) over repeat visits. Proximal pulse waves were acquired (applanation tonometry) from the left common carotid (CCA) for both measures, while distal pulse waves were acquired from the left femoral artery (applanation tonometry) and the second left toe (pulse oximeter) for cfPWV and ctPWV, respectively.

Results: cfPWV (5.3 ± 0.7, 3.9–6.5 m/s) and ctPWV (5.4 ± 0.5, 4.6–6.3 m/s) demonstrated a moderate-to-strong positive linear correlation (r = 0.79, P < 0.01) and a strong intra-class correlation (ICC; ICC = 0.86, P < 0.01). The Bland–Altman plot demonstrated agreement between cfPWV and ctPWV with no fixed bias (0.1 m/s, ± 2SD: −0.8 to 0.9 m/s, P > 0.05) and all data points falling within ±2 SD of the mean difference between measures. cfPWV and ctPWV demonstrated reliability across visits as evidenced by low coefficients of variation (cfPWV: 3.4 ± 2.6%, ctPWV: 2.6 ± 2.5%) and strong ICCs (cfPWV: ICC = 0.91, ctPWV: ICC = 0.84, both P < 0.01).

Conclusions: Through comparison with cfPWV, this study provides evidence to suggest that ctPWV yields a valid and reliable index of arterial stiffness in healthy young adults.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
23 - C
Pages
32 - 38
Publication Date
2018/07
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2018.07.001How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Stephen A. Klassen
AU  - Kylie S. Dempster
AU  - Daniele Chirico
AU  - Deborah D. O’Leary
PY  - 2018
DA  - 2018/07
TI  - Validity and reliability of carotid-toe pulse wave velocity as a measure of arterial stiffness in healthy individuals: Comparison to carotid-femoral pulse wave velocity
JO  - Artery Research
SP  - 32
EP  - 38
VL  - 23
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.07.001
DO  - https://doi.org/10.1016/j.artres.2018.07.001
ID  - Klassen2018
ER  -