Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study
- https://doi.org/10.1016/j.artres.2018.05.006How to use a DOI?
- Coronary artery calcification, BMP-2 – BMP-7, SMAD signaling pathway, TGF-β
Background: Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk. BMP-2 is a powerful inducer of bone formation and exposure to BMP-2 in the arteries leads to the loss of vascular smooth muscle cells (VSMC) markers and increase gene expression in favor of osteoblasts. BMP-7 is key factor in the bone and kidney and is suggested as inhibitor of vascular calcification. The main purpose of this clinical study was to find out the correlation between BMP-2 and BMP-7serum concentration and CAC in human for the first time.
Methods: In this study 84 patients with coronary artery disease who fulfilled inclusion and exclusion criteria, entered the study. For all patients a questionnaire consisting demographic data and traditional cardiovascular risk factors were completed. CT-Angiography was carried out to determine coronary artery calcium score and ELISA method was used for measuring BMP-2 and BMP-7serum concentrations.
Results: There was a significant positive correlation between BMP-2 serum concentration and total CAC score and also CAC of right coronary artery (RCA), left anterior descending (LAD), circumflex (CX), left main coronary artery (LMCA) (P < 0.05). Similar result was found for BMP-7 serum concentration except in LMCA (P > 0.05).
Conclusion: Based on our results, we can suggest BMP-2 and BMP-7 serum concentration as a probable biomarker for coronary artery disease. However, more studies with higher sample size are necessary for its confirmation.
- © 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
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Cite this article
TY - JOUR AU - Saeed Nazemi AU - Atefeh Rezapour AU - Seyed Mohammad Hasan Moallem AU - Mohammad Afshar AU - Sepideh Elyasi AU - Elham Hashemi AU - Sheyda Golmohammadzadeh AU - Azadeh Zaerzadeh AU - Vahid Jomezadeh AU - Amir Hooshang Mohammadpour PY - 2018 DA - 2018/05 TI - Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study JO - Artery Research SP - 14 EP - 19 VL - 23 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2018.05.006 DO - https://doi.org/10.1016/j.artres.2018.05.006 ID - Nazemi2018 ER -