Artery Research

Volume 23, Issue C, September 2018, Pages 14 - 19

Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study

Authors
Saeed Nazemia, Atefeh Rezapourb, Seyed Mohammad Hasan Moallemc, Mohammad Afshard, e, Sepideh Elyasib, Elham Hashemif, Sheyda Golmohammadzadeha, Azadeh Zaerzadehb, Vahid Jomezadehg, Amir Hooshang Mohammadpourb, h, *
aDepartment of Cardiovascular Diseases, Razavi Hospital, Mashhad, Iran
bDepartment of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
cFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
dDepartment of Anatomy, Birjand University of Medical Sciences, Birjand, Iran
eMedical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
fBirjand Cardiovascular Disease Research Center, Department of Cardiology, Birjand University of Medical Sciences, Birjand, Iran
gDepartment of Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
hPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding author. P.O. Box 91775-1365, Mashhad, Iran. Fax: +985138823251. E-mail address: MohamadpoorAH@mums.ac.ir (A.H. Mohammadpour).
Corresponding Author
Amir Hooshang Mohammadpour
Received 31 December 2017, Revised 8 May 2018, Accepted 14 May 2018, Available Online 29 May 2018.
DOI
https://doi.org/10.1016/j.artres.2018.05.006How to use a DOI?
Keywords
Coronary artery calcification, BMP-2 – BMP-7, SMAD signaling pathway, TGF-β
Abstract

Background: Coronary artery calcification (CAC) is utilized as an important tool for the global risk assessment of cardiovascular events in individuals with intermediate risk. BMP-2 is a powerful inducer of bone formation and exposure to BMP-2 in the arteries leads to the loss of vascular smooth muscle cells (VSMC) markers and increase gene expression in favor of osteoblasts. BMP-7 is key factor in the bone and kidney and is suggested as inhibitor of vascular calcification. The main purpose of this clinical study was to find out the correlation between BMP-2 and BMP-7serum concentration and CAC in human for the first time.

Methods: In this study 84 patients with coronary artery disease who fulfilled inclusion and exclusion criteria, entered the study. For all patients a questionnaire consisting demographic data and traditional cardiovascular risk factors were completed. CT-Angiography was carried out to determine coronary artery calcium score and ELISA method was used for measuring BMP-2 and BMP-7serum concentrations.

Results: There was a significant positive correlation between BMP-2 serum concentration and total CAC score and also CAC of right coronary artery (RCA), left anterior descending (LAD), circumflex (CX), left main coronary artery (LMCA) (P < 0.05). Similar result was found for BMP-7 serum concentration except in LMCA (P > 0.05).

Conclusion: Based on our results, we can suggest BMP-2 and BMP-7 serum concentration as a probable biomarker for coronary artery disease. However, more studies with higher sample size are necessary for its confirmation.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
23 - C
Pages
14 - 19
Publication Date
2018/05
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2018.05.006How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Saeed Nazemi
AU  - Atefeh Rezapour
AU  - Seyed Mohammad Hasan Moallem
AU  - Mohammad Afshar
AU  - Sepideh Elyasi
AU  - Elham Hashemi
AU  - Sheyda Golmohammadzadeh
AU  - Azadeh Zaerzadeh
AU  - Vahid Jomezadeh
AU  - Amir Hooshang Mohammadpour
PY  - 2018
DA  - 2018/05
TI  - Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study
JO  - Artery Research
SP  - 14
EP  - 19
VL  - 23
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.05.006
DO  - https://doi.org/10.1016/j.artres.2018.05.006
ID  - Nazemi2018
ER  -