Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men
- https://doi.org/10.1016/j.artres.2018.08.001How to use a DOI?
- Resistance training, Carotid arterial compliance, Vasoconstrictive mediator, Platelet aggregation, Young men
Background: Reduction in central arterial compliance is an independent risk factor for cardiovascular disease, and is caused by high-intensity resistance training. The thromboxane has both potent vasoconstrictive and platelet aggregation effects, and is associated with cardiovascular diseases. However, whether thromboxane is involved in resistance training-induced decrease in central arterial compliance is unclear. The present study aimed to investigate relationships between circulating thromboxane levels and central arterial compliance in both cross-sectional and longitudinal (i.e., resistance training) designs.
Methods and results: First, in a cross-sectional study, we assessed association between circulating thromboxane concentrations and central arterial compliance in 63 young men, who showed significant negative correlation between those parameters. Second, in a longitudinal study, we examined effects of high-intensity resistance training on circulating thromboxane concentrations and central arterial compliance and relationship among changes from baseline in those parameters. Young sedentary men were assigned to control (n = 7) or training (n = 17) groups. Subjects in training group underwent four-week supervised high-intensity resistance training. Resistance training significantly elevated circulating thromboxane concentrations and decreased central arterial compliance; no significant change was observed in control group, and there was significant correlation between changes in those parameters.
Conclusions: circulating thromboxane is possible mechanism explaining resistance training-induced decrease in central arterial compliance in young men.
- © 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
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Cite this article
TY - JOUR AU - Kaname Tagawa AU - Song-Gyu Ra AU - Hiroshi Kumagai AU - Yuriko Sawano AU - Kosaku Yamamoto AU - Toru Yoshikawa AU - Youngju Choi AU - Yasuko Yoshida AU - Kazuhiro Takekoshi AU - Seiji Maeda PY - 2018 DA - 2018/09 TI - Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men JO - Artery Research SP - 63 EP - 70 VL - 23 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2018.08.001 DO - https://doi.org/10.1016/j.artres.2018.08.001 ID - Tagawa2018 ER -