Artery Research

Volume 23, Issue C, September 2018, Pages 63 - 70

Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men

Authors
Kaname Tagawaa, Song-Gyu Rab, Hiroshi Kumagaic, Yuriko Sawanoa, Kosaku Yamamotoa, Toru Yoshikawaa, Youngju Choid, Yasuko Yoshidaa, Kazuhiro Takekoshie, Seiji Maedad, *
aGraduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
bFaculty of Sports and Health Science, Fukuoka University, Japan
cFaculty of Health and Sports Science, Juntendo University, Japan
dFaculty of Health and Sport Sciences, University of Tsukuba, Japan
eFaculty of Medicine, University of Tsukuba, Japan
*Corresponding author. Division of Sports Medicine, Faculty of Health and Sport Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan. Fax: +81 29 853 2986. E-mail address: maeda.seiji.gn@u.tsukuba.ac.jp (S. Maeda).
Corresponding Author
Seiji Maeda
Received 22 February 2018, Revised 12 July 2018, Accepted 14 August 2018, Available Online 18 September 2018.
DOI
https://doi.org/10.1016/j.artres.2018.08.001How to use a DOI?
Keywords
Resistance training, Carotid arterial compliance, Vasoconstrictive mediator, Platelet aggregation, Young men
Abstract

Background: Reduction in central arterial compliance is an independent risk factor for cardiovascular disease, and is caused by high-intensity resistance training. The thromboxane has both potent vasoconstrictive and platelet aggregation effects, and is associated with cardiovascular diseases. However, whether thromboxane is involved in resistance training-induced decrease in central arterial compliance is unclear. The present study aimed to investigate relationships between circulating thromboxane levels and central arterial compliance in both cross-sectional and longitudinal (i.e., resistance training) designs.

Methods and results: First, in a cross-sectional study, we assessed association between circulating thromboxane concentrations and central arterial compliance in 63 young men, who showed significant negative correlation between those parameters. Second, in a longitudinal study, we examined effects of high-intensity resistance training on circulating thromboxane concentrations and central arterial compliance and relationship among changes from baseline in those parameters. Young sedentary men were assigned to control (n = 7) or training (n = 17) groups. Subjects in training group underwent four-week supervised high-intensity resistance training. Resistance training significantly elevated circulating thromboxane concentrations and decreased central arterial compliance; no significant change was observed in control group, and there was significant correlation between changes in those parameters.

Conclusions: circulating thromboxane is possible mechanism explaining resistance training-induced decrease in central arterial compliance in young men.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
23 - C
Pages
63 - 70
Publication Date
2018/09
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2018.08.001How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Kaname Tagawa
AU  - Song-Gyu Ra
AU  - Hiroshi Kumagai
AU  - Yuriko Sawano
AU  - Kosaku Yamamoto
AU  - Toru Yoshikawa
AU  - Youngju Choi
AU  - Yasuko Yoshida
AU  - Kazuhiro Takekoshi
AU  - Seiji Maeda
PY  - 2018
DA  - 2018/09
TI  - Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men
JO  - Artery Research
SP  - 63
EP  - 70
VL  - 23
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.08.001
DO  - https://doi.org/10.1016/j.artres.2018.08.001
ID  - Tagawa2018
ER  -