Proceedings of the National Seminar on Chemistry 2019 (SNK-19)

Histopathology of Kidney In Mice (Mus musculus L) Indicated By Pre-Diabetes Mellitus Type 2 (Pre-Type 2 DM) With a variation of Yeast Treatment

Authors
Rudiana Agustini, Erlix Rakhmad Purnama, Agus Widodo
Corresponding Author
Rudiana Agustini
Available Online December 2019.
DOI
10.2991/snk-19.2019.17How to use a DOI?
Keywords
mice, pre-type 2 DM, yeast-red rice, YHE red rice, histopathology of kidney
Abstract

A kidney is an organ that has many roles to survive. This organ can be damaged by type 2 diabetes mellitus which is marked by high glucose in the blood. Histological studies of kidney tissue in mice (Mus musculus L.) shown by type 2 pre-Diabetes Mellitus with variations in yeast treatment have been carried out. This study uses variations in the treatment of yeast planted in red rice (red yeast) and yeast extract produced by enzymatic hydrolysis (YHE-red rice) as a comparison. Mice as experimental animals were induced by obesity using a high-fat and fructose diet so they showed symptoms of Pre-DM type 2 and were then treated with red yeast rice and red YHE-rice. This study used a comparison of mice shown by DM and treated with glibenclamide in CMC-Na 0.2% (positive control), mice that showed DM and treated with CMC-Na 0.2% (negative control), and non-DM rats and treated with CMC -Na 0.2% (normal control). Observation of renal histopathology using a light microscope. Parameters observed included those characterized by cell necrosis, glomerular nephropathy, increased thickness of Bowman's space, thickening of the distal and proximal tubules, thickening of the renal arteries, and leukocyte infiltration. The results showed that the kidneys of rats that were indicated type-2 DM and yeast-BM and YE-BM, as well as rats that indicated DM and were treated with glibenclamide in 0.2% CMC-Na for 1 week, were performed. did not show histological differences. Kidney when compared with non-DM mice and treated with 0.2% CMC-Na (normal control), as well as mice that were indicated by DM and treated with 0.2 CMC-Na. So to find out the effect of yeast treatment on the kidney of mice indicated by type 2 DM, it is necessary to induce obesity and treat yeast-red rice or YHE-red rice for longer periods

Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the National Seminar on Chemistry 2019 (SNK-19)
Series
Atlantis Highlights in Chemistry and Pharmaceutical Sciences
Publication Date
December 2019
ISBN
978-94-6252-877-2
ISSN
2590-3195
DOI
10.2991/snk-19.2019.17How to use a DOI?
Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Rudiana Agustini
AU  - Erlix Rakhmad Purnama
AU  - Agus Widodo
PY  - 2019/12
DA  - 2019/12
TI  - Histopathology of Kidney In Mice (Mus musculus L) Indicated By Pre-Diabetes Mellitus Type 2 (Pre-Type 2 DM) With a variation of Yeast Treatment
BT  - Proceedings of the National Seminar on Chemistry 2019 (SNK-19)
PB  - Atlantis Press
SP  - 22
EP  - 27
SN  - 2590-3195
UR  - https://doi.org/10.2991/snk-19.2019.17
DO  - 10.2991/snk-19.2019.17
ID  - Agustini2019/12
ER  -