Sex Hormone and Sex Hormone Receptors Modulation of Exercise-induced Neurogenesis
- DOI
- 10.2991/assehr.k.211011.099How to use a DOI?
- Keywords
- exercise-induced neurogenesis, sex hormones, sex hormone receptors, depression-like behavior
- Abstract
Adult hippocampal neurogenesis (AHN) has been widely studied in many aspects. AHN is showed to have causal relationship with depression and anxiety. Experimental data showed that sex hormones and sex hormone receptors can be a factor that modulates AHN. However, few studies have focused on sex hormones’ effect on exercise-induced neurogenesis, which the detailed mechanism is unknown to people. In this paper, we designed the experiments to find a casual relationship between sex hormones (receptors) and exercise-induced neurogenesis. We utilized castration (TX) and ovariectomy (OVX) to control the hormone level within the rats’ body. Noteworthy, we also tested how can the numerical ratios of androgen to estrogen and androgen receptors to estrogen receptors affect exercise-induced neurogenesis by using conditional gene knockout and Cre recombinase. If the results turn out to be consistent with the hypothesis that the level of sex hormones and sex hormone receptors have influences on exercise-induced neurogenesis and depression-like behavior, we can put forward a treatment on anxiety disorders concerning the combination of exercise and sex hormone regulation.
- Copyright
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Peiyi Liu PY - 2021 DA - 2021/10/12 TI - Sex Hormone and Sex Hormone Receptors Modulation of Exercise-induced Neurogenesis BT - Proceedings of the 2021 6th International Conference on Modern Management and Education Technology（MMET 2021） PB - Atlantis Press SP - 543 EP - 548 SN - 2352-5398 UR - https://doi.org/10.2991/assehr.k.211011.099 DO - 10.2991/assehr.k.211011.099 ID - Liu2021 ER -