Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology

Study on Synthesis of 6-Pentyl-tetrahydro-thieno[3,4-d]imidazol-2-one

Authors
Cheng Liang, ShuangLin Qin, Shuangping Huang, Xiaoji Wang
Corresponding Author
Cheng Liang
Available Online December 2015.
DOI
10.2991/mmeceb-15.2016.162How to use a DOI?
Keywords
6-Pentyl-tetrahydro-thieno[3,4-d]imidazol-2-one, Biotin, 5-(2-Oxo-hexahydro-thieno [3,4-d]imidazol-6-yl)-pentanoic acid ,synthesis
Abstract

A synthetic route from 5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (biotin) to 6-Pentyl-tetrahydr o-thieno [3,4-d] imidazol-2-one which have important antibacterial bioactivity was described. The whole route processed in overall 56% yield, including an esterification, a DIBAL-H reduction, a protection and a reduction.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
Series
Advances in Engineering Research
Publication Date
December 2015
ISBN
978-94-6252-151-3
ISSN
2352-5401
DOI
10.2991/mmeceb-15.2016.162How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Cheng Liang
AU  - ShuangLin Qin
AU  - Shuangping Huang
AU  - Xiaoji Wang
PY  - 2015/12
DA  - 2015/12
TI  - Study on Synthesis of 6-Pentyl-tetrahydro-thieno[3,4-d]imidazol-2-one
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 813
EP  - 816
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.162
DO  - 10.2991/mmeceb-15.2016.162
ID  - Liang2015/12
ER  -