Synthesis of 6, 4’’-Di-O-methylerythromycin A and its derivatives

DOI

10.2991/mmeceb-15.2016.113How to use a DOI?

Keywords

Soccer 6,4’’-Di-O-methylerythromycin A; Clarithromycin; Synthesis

Abstract

6,4’’-Di-O-methylerythromycin A is a relative substance of clarithromycin, which is due to incomplete protection of 4’’-OH during the methylation process. In this study, 6,4’’-Di- O-methylerythromycin A(5) and its derivatives including 2’-O-TMS-6-O-methylerythromycin A 9-[(1-ethoxy-1-methylethyl)oxime](2), 2’-O-TMS-6,4’’-Di-O-methylerythromycin A 9-[(1-ethoxy- 1-methylethyl)oxime](3) and 6,4’’-Di-O-methylerythromycin A 9-oxime(4) was synthesized from 2’,4’’-O-bis(TMS)-6-O-methylerythromycin A 9-[(1-ethoxy-1-methylethyl)oxime](1). The struc- ture of each compound was identified by 1H-NMR and 13C-NMR..

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Liquan Sun
AU  - BuFang Ma
AU  - GuoWei Yao
PY  - 2015/12
DA  - 2015/12
TI  - Synthesis of 6, 4’’-Di-O-methylerythromycin A and its derivatives
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 574
EP  - 578
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.113
DO  - 10.2991/mmeceb-15.2016.113
ID  - Sun2015/12
ER  -