Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology

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Effect of total flavonoids of Epimedium on climacteric depression model

Authors
Mingsan Miao, Peng Xi, Bolin Cheng, Mengfei Zhang, Tisheng Cui
Corresponding Author
Mingsan Miao
Available Online December 2015.
DOI
10.2991/mmeceb-15.2016.8How to use a DOI?
Keywords
total flavonoids of Epimedium climacteric depression model Gengnian'an capsule group Soybean isoflavone group
Abstract

Objective:To study effect of total flavonoids of Epimedium on climacteric depression model. Methods: In addition to the blank group, other rats climacteric models, total removal of the left ovary, the right ovary removed 80%. After the injection of penicillin to prevent infection, continuous injection 3 days, operation started by only for vaginal smear of rats after 5 d, one times a day, a continuous smear 5 days, smear showing estrous response of the animal discard without, selection of animal 60 castrated completely random divided into 6 groups for the experiment. After two weeks of administration, the normal group was not given any stimulus, to make the model of group of single cage monoculture, everyday to given different stimulation. Result: The total flavonoids of Epimedium large, middle, small dose can significantly improve the depressive rats 24h sucrose intake, horizontal and vertical integral of motion, levels of 5-HT and DA in brain homogenate, thymus index, the uterus index, the level of serum E2 The decrease of levels of serum LH, FSH, the elevation of serum IL-2, to improve the content of BGP in serum. Conclusion: The total flavonoids of Epimedium each dose of each index of perimenopausal depression model rats have avery good improvement.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
Series
Advances in Engineering Research
Publication Date
December 2015
ISBN
10.2991/mmeceb-15.2016.8
ISSN
2352-5401
DOI
10.2991/mmeceb-15.2016.8How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Mingsan Miao
AU  - Peng Xi
AU  - Bolin Cheng
AU  - Mengfei Zhang
AU  - Tisheng Cui
PY  - 2015/12
DA  - 2015/12
TI  - Effect of total flavonoids of Epimedium on climacteric depression model
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 38
EP  - 44
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.8
DO  - 10.2991/mmeceb-15.2016.8
ID  - Miao2015/12
ER  -