Pathological Features of Pancreatic Endocrine Tumor and Its Differential Diagnosis with Acinic Cell Carcinoma

DOI

10.2991/mmeceb-15.2016.5How to use a DOI?

Keywords

Pancreatic endocrine tumor, Pancreatic acinar cell carcinoma, Pathological features, Differential diagnosis

Abstract

Purpose: analyze the pathological features of pancreatic endocrine tumor and discuss the differential diagnosis of pancreatic endocrine tumor and pancreatic acinic cell carcinoma. Method: choose 10 patients of pancreatic endocrine tumor from the Chinese Medicine Hospital of Henan Province and the Tumor Consultation Center of Henan Province during January 2012 to January 2015 as research object to analyze their pathological features; choose another 10 patients of pancreatic acinic cell carcinoma conformed during the same period to make control study, combine the pathological examination and documentations to male differential diagnosis for pancreatic endocrine tumor and pancreatic acinic cell carcinoma. Result: (1)for cell morphology, tumor cells of the pancreatic endocrine tumor are arranged as solid flakes, aciniform and trabecular, its organizational structure is similar with that of pancreatic acinic cell carcinoma, but the organization of pancreatic endocrine tumor has no heterocyst, while the organization of pancreatic acinic cell carcinoma has heterocyst. (2) For the expression of immunohistochemistry, the pan cytokeratin, synaptophysin and chromogranin of the patients of pancreatic endocrine tumor and pancreatic acinic cell carcinoma are all positive, while the expression of vimentin, epithelial membrane antigen and insulin of the two kinds of pancreatic tumor are different. (3) For Clinical biological behavior, only one of the ten pancreatic endocrine tumor was diagnosed to be pancreatic tail neuroendocrine carcinoma, tumor of other nine patients were benign, while ten pancreatic acinar cell carcinoma were all high aggressive malignant tumor. Conclusion: Most of the pancreatic endocrine tumors are benign, while pancreatic acinar cell carcinoma is a kind of malignant tumor, though the cellular morphology of two kinds of tumor are similar, while there is obvious difference on the aspect of biological behavior of two kinds of tumors, clinical differential diagnosis of these two kinds of tumors should be paid attention.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zichuang Wang
AU  - XiaoYong Chen
PY  - 2015/12
DA  - 2015/12
TI  - Pathological Features of Pancreatic Endocrine Tumor and Its Differential Diagnosis with Acinic Cell Carcinoma
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 21
EP  - 24
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.5
DO  - 10.2991/mmeceb-15.2016.5
ID  - Wang2015/12
ER  -