Proceedings of the 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer

Preparation and characterization of FA conjuagted MPEG-PLA polymer nanoparticles loaded with 10-hydroxycamptothecin for sustained drug release

Authors
Huijuan Liu, Jinbing Yang, Xiangrui Yang, Shichao Wu, Mengmeng Jia, Liya Xie, Zhenqing Hou
Corresponding Author
Huijuan Liu
Available Online June 2016.
DOI
10.2991/mmebc-16.2016.142How to use a DOI?
Keywords
10-Hydroxycamptothecin, Self-assembly, PEG-b-PLA, Folate, Nanoparticles.
Abstract

Suboptimal pharmacokinetic properties, such as poor water solubility, limited stability, and severe side effects, still limited the therapeutic efficacy of drug for cancer chemotherapy, but there has been many strategies to improve these properties. In this paper, we combined several methods in a single drug delivery system and prepared a kind of 10-hydroxycamptothecin (HCPT)-loaded, PEGylated and folate modified polymeric nanoparticles (NPs). The results showed that the HCPT-MPEG-PLA-FA NPs (HMPF NPs) presented a hydrodynamic particle size of about 200 nm, a zeta potential of -8.9 mV, drug encapsulation efficiency of 67.77%, and drug-loading content of 8.23%. The in vitro drug release experiments exhibited a slow and prolonged release profile over 160 h. These results suggested that the HMPF NPs were well suited for drug delivery.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer
Series
Advances in Engineering Research
Publication Date
June 2016
ISBN
978-94-6252-210-7
ISSN
2352-5401
DOI
10.2991/mmebc-16.2016.142How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Huijuan Liu
AU  - Jinbing Yang
AU  - Xiangrui Yang
AU  - Shichao Wu
AU  - Mengmeng Jia
AU  - Liya Xie
AU  - Zhenqing Hou
PY  - 2016/06
DA  - 2016/06
TI  - Preparation and characterization of FA conjuagted MPEG-PLA polymer nanoparticles loaded with 10-hydroxycamptothecin for sustained drug release
BT  - Proceedings of the 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer
PB  - Atlantis Press
SP  - 671
EP  - 674
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmebc-16.2016.142
DO  - 10.2991/mmebc-16.2016.142
ID  - Liu2016/06
ER  -