Molecular Mechanisms of Vascular Calcification in Diabetes Mellitus: Insights from Human Aortic Smooth Muscle Cells, A Systematic Review

DOI

10.2991/978-94-6463-807-3_5How to use a DOI?

Keywords

Dapagliflozin; Diabetes Mellitus; Metformin; Efficacy

Abstract

Vascular calcification is a significant contributor to cardiovascular complications in diabetes mellitus (DM), particularly affecting the prognosis of patients. This review conducts a comprehensive analysis of the molecular mechanisms underlying vascular calcification in DM, with a focus on insights from human aortic smooth muscle cells (HASMCs). The search was conducted following the PRISMA guidelines, utilizing databases such as MEDLINE/PubMed, Science Direct, and Google Scholar. The search focused on articles published within the last 5 years that discussed the molecular mechanisms of vascular calcification in DM, specifically in HASMCs. Five selected reviews were found in a total of 637 articles. DM significantly accelerates vascular calcification in HASMCs through the upregulation of osteogenic markers and activation of the Wnt/β-catenin signaling pathway. Other identified mechanisms include inflammation, ferroptosis, and endothelial dysfunction, contributing to the complex interplay of factors that drive vascular calcification in diabetic patients. It is concluded that DM significantly accelerates vascular calcification in enhanced expression of osteogenic markers and activation of the Wnt/β-catenin signaling pathway in human aortic smooth muscle cells. Patients with diabetes are more likely to have cardiovascular issues as a result of this pathological process.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Anditri Weningtyas
AU  - Mohammad Saifur Rohman
AU  - Indah Nur Chomsy
AU  - Victor Alvianoes Guterez Hose
AU  - Mochamad Faishal Riza
AU  - Dian Laila Purbaningroom
AU  - Achmad Rudijanto
AU  - Dian Nugrahenny
PY  - 2025
DA  - 2025/09/17
TI  - Molecular Mechanisms of Vascular Calcification in Diabetes Mellitus: Insights from Human Aortic Smooth Muscle Cells, A Systematic Review
BT  - Proceedings of the Malang International Conference in Medical and Health Sciences (MICROMEDHS 2024)
PB  - Atlantis Press
SP  - 52
EP  - 65
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-807-3_5
DO  - 10.2991/978-94-6463-807-3_5
ID  - Weningtyas2025
ER  -