The Role of Platelet-to-Lymphocyte Ratio in Inflammation-Related Disease: A Bibliometric Analysis And Scientific Mapping

DOI

10.2991/978-94-6463-807-3_4How to use a DOI?

Keywords

Platelet-to-Lymphocyte Ratio; PLR; Inflammation; Bibliometric Analysis

Abstract

This bibliometric analysis explores the growing relevance of the Platelet-to-Lymphocyte Ratio (PLR) as a biomarker for inflammation across a range of diseases. Using Scopus data from 2019 to 2024, we examined 1,801 publications, visualizing keyword co-occurrences and networks through VOSviewer. Key terms such as “human,” “lymphocyte count,” and “C-reactive protein” illustrate PLR’s connections to various clinical contexts. Findings reveal that PLR serves as a cost-effective and accessible biomarker, particularly relevant in areas like cancer prognosis, cardiovascular disease, and autoimmune conditions. Studies increasingly demonstrate that elevated PLR values correlate with worse clinical outcomes, underscoring its potential in assessing disease severity. International interest in PLR research is evident, with significant contributions from China, Turkey, and the United States, positioning these countries as leading research hubs. The temporal analysis of publication trends highlights a shift from PLR’s initial use primarily in cancer prognosis to broader applications in chronic disease management, especially inflammatory disorders. This expansion underscores PLR’s role in the emerging discussions on systemic inflammation and chronic disease risk factors in healthcare. Through co-occurrence analysis, clusters of keywords provide a thematic map, linking PLR with various hematological and inflammatory markers, as well as demographic factors, which reflect its utility in both diagnosis and monitoring. Thematic clusters also emphasize PLR’s integration into studies on systemic inflammation, where it helps in tracking disease progression and patient outcomes. Research contributions mapped geographically and by authors highlight the growing influence of key researchers in expanding the scope of PLR applications. Data trends from a rapid increase in 2020 to recent stabilization suggest PLR is becoming an established component in the study of inflammation. This analysis supports PLR’s potential to guide clinical practices, advocating for further research to enhance its application in chronic inflammatory disease management and personalized medicine.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Karina Nilasari
AU  - Andrew Halim
AU  - R. Dimas Nur
AU  - Shabrina Nurdiar
AU  - Filza Kamilanisa
AU  - Rosa Maghfirah
AU  - R. Izzah Fadhilah
AU  - nayaka Althafsyah
AU  - Rokhmatul Asiyah
PY  - 2025
DA  - 2025/09/17
TI  - The Role of Platelet-to-Lymphocyte Ratio in Inflammation-Related Disease: A Bibliometric Analysis And Scientific Mapping
BT  - Proceedings of the Malang International Conference in Medical and Health Sciences (MICROMEDHS 2024)
PB  - Atlantis Press
SP  - 41
EP  - 51
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-807-3_4
DO  - 10.2991/978-94-6463-807-3_4
ID  - Nilasari2025
ER  -