Alpha-fetoprotein Epitope Peptide Promoted the Proliferation of Primary Hepatocellular Carcinoma Cells

DOI

10.2991/meita-15.2015.108How to use a DOI?

Keywords

Alpha-fetoprotein (AFP); Epitope Peptide; Proliferation; Hepatocellular Carcinoma (HCC)

Abstract

Alpha-fetoprotein (AFP) is an oncofetal protein during hepatocellular carcinoma (HCC) development which could promote tumor growth and inhibit active immunity, and it may serve as a target for immunotherapy. To further confirm the immunogenicity of AFP, we constructed a AFP eitope peptide vaccine which contained the specific antigen epitope. Our results demonstrated that although AFP epitope peptide induced a distinct level of antibody, it still inhibited dendritic cells, CD8+ T cells, natural killer cells responses and promoted the growth of AFP-expressing tumors. Our study suggests that AFP epitope peptide promoted the proliferation of hepatocellular carcinoma by inhibiting the effects of immune cells,which may be a better basis for further study on HCC immunotherapy.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Huanping Lin
AU  - Xiaoping Wang
AU  - Bing Xu
AU  - Qian Zhao
AU  - Ke-pei Zhang
AU  - Pengfei Zhang
PY  - 2015/08
DA  - 2015/08
TI  - Alpha-fetoprotein Epitope Peptide Promoted the Proliferation of Primary Hepatocellular Carcinoma Cells
BT  - Proceedings of the 2015 International Conference on Materials Engineering and Information Technology Applications
PB  - Atlantis Press
SP  - 591
EP  - 595
SN  - 2352-5401
UR  - https://doi.org/10.2991/meita-15.2015.108
DO  - 10.2991/meita-15.2015.108
ID  - Lin2015/08
ER  -