Alpha-fetoprotein Epitope Peptide Promoted the Proliferation of Primary Hepatocellular Carcinoma Cells
- 10.2991/meita-15.2015.108How to use a DOI?
- Alpha-fetoprotein (AFP); Epitope Peptide; Proliferation; Hepatocellular Carcinoma (HCC)
Alpha-fetoprotein (AFP) is an oncofetal protein during hepatocellular carcinoma (HCC) development which could promote tumor growth and inhibit active immunity, and it may serve as a target for immunotherapy. To further confirm the immunogenicity of AFP, we constructed a AFP eitope peptide vaccine which contained the specific antigen epitope. Our results demonstrated that although AFP epitope peptide induced a distinct level of antibody, it still inhibited dendritic cells, CD8+ T cells, natural killer cells responses and promoted the growth of AFP-expressing tumors. Our study suggests that AFP epitope peptide promoted the proliferation of hepatocellular carcinoma by inhibiting the effects of immune cells,which may be a better basis for further study on HCC immunotherapy.
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Huanping Lin AU - Xiaoping Wang AU - Bing Xu AU - Qian Zhao AU - Ke-pei Zhang AU - Pengfei Zhang PY - 2015/08 DA - 2015/08 TI - Alpha-fetoprotein Epitope Peptide Promoted the Proliferation of Primary Hepatocellular Carcinoma Cells BT - Proceedings of the 2015 International Conference on Materials Engineering and Information Technology Applications PB - Atlantis Press SP - 591 EP - 595 SN - 2352-5401 UR - https://doi.org/10.2991/meita-15.2015.108 DO - 10.2991/meita-15.2015.108 ID - Lin2015/08 ER -