Wound Healing Acceleration of Spatholobus littoralis Extract on Rat Incision Wound Infected by Staphylococcus aureus: A Preliminary Study

DOI

10.2991/978-94-6463-457-0_16How to use a DOI?

Keywords

Spatholobus littoralis; Staphylococcus aureus; incision wound length

Abstract

The efficacy of Spatholobus littoralis extract for incision wound is not fully understood. Here, we report the wound healing activities of Spatholobus littoralis extracts in incision wound models in rat. The aim of the study was to measure the wound length on rat’s incision wound infected by Staphylococcus aureus. Fifteen male Rattus norvegicus rats weighing 200-250 g were randomly divided into four groups: (1) negative control (natural healing); (2) positive control (amoxicillin 10 mg); (3) 2.5 mg/kg/bw Spatholobus littoralis extract treatment; (4) 25 mg/kg/bw Spatholobus littoralis extract treatment. The treatment substances were applied topically daily. The length of the incision wound was measured every day after wound infliction. The results of the incision wound length measurement in treatment group showed better results; in average, the 2.5 mg Spatholobus littoralis extract treatment group showed that the wound was totally closed on day 13, and the 25 mg bajakah extract treatment group showed the wound closure on day 12. Meanwhile, the positive control group showed the wound closure on day 14 and negative control group wounds are not closed yet until day 14. The treatment with bajakah extract have an advantage on wound closure on male rats infected with Staphylococcus aureus.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Arya Iswara
AU  - Fatchul Ulum
AU  - Fitri Nuroini
AU  - Tulus Ariyadi
AU  - Mustika Sari
PY  - 2024
DA  - 2024/07/22
TI  - Wound Healing Acceleration of Spatholobus littoralis Extract on Rat Incision Wound Infected by Staphylococcus aureus: A Preliminary Study
BT  - Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences: Medical Laboratory Technology (LSISHS-MLT 2023)
PB  - Atlantis Press
SP  - 133
EP  - 141
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-457-0_16
DO  - 10.2991/978-94-6463-457-0_16
ID  - Iswara2024
ER  -