Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences: Medical Laboratory Technology (LSISHS-MLT 2023)

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rs841853 of SLC2A1 Gene Polymorphism and Dyslipidemia Among Javanese Type 2 Diabetes Mellitus Patients

Authors
Yanuarita Tursinawati1, *, Ari Yuniastuti2
1Universitas Muhammadiyah Semarang, Semarang, Central Java, 50273, Indonesia
2Universitas Negeri Semarang, Semarang, Central Java, 50229, Indonesia
*Corresponding author. Email: yanuarita_tursina@unimus.ac.id
Corresponding Author
Yanuarita Tursinawati
Available Online 22 July 2024.
DOI
10.2991/978-94-6463-457-0_10How to use a DOI?
Keywords
Polymorphism; SLC2A1 gene; Dyslipidemia; Type 2 Diabetes Mellitus; Javanese
Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic disease indicated by blood sugar level disorder and also influenced by genetic and environmental factors. Many diabetes patients experience dyslipidemia, which is known as diabetic dyslipidemia. In the latest research, SLC2A1 gene polymorphism is strongly related to T2DM. This research aimed to investigate the involvement of rs841853 of SLC2A1 gene polymorphism in Javanese diabetes patients with dyslipidemia.This cross-sectional study involved 107 T2DM patients as the sample to verify polymorphism. The occurrence of polymorphism was done using the PCR-RFLP method. The mean of the laboratory characteristic among groups was tested using an independent t-test with a significance of p < 0.05. In both groups, G allele (wild type) and GG genotype were mostly found. There was no difference in allele frequency (p=0.185) and genotype frequency (p=0.238). The differences of laboratory characteristic between the GG genotype and TG + TT genotype, either in dyslipidemia or non-dyslipidemia, showed no significance (p>0.05). Rs841853 of SLC2A1 gene polymorphism was not a significant risk factor for dyslipidemia in Javanese T2DM patients.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences: Medical Laboratory Technology (LSISHS-MLT 2023)
Series
Advances in Biological Sciences Research
Publication Date
22 July 2024
ISBN
978-94-6463-457-0
ISSN
2468-5747
DOI
10.2991/978-94-6463-457-0_10How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Yanuarita Tursinawati
AU  - Ari Yuniastuti
PY  - 2024
DA  - 2024/07/22
TI  - rs841853 of SLC2A1 Gene Polymorphism and Dyslipidemia Among Javanese Type 2 Diabetes Mellitus Patients
BT  - Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences: Medical Laboratory Technology (LSISHS-MLT 2023)
PB  - Atlantis Press
SP  - 87
EP  - 93
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-457-0_10
DO  - 10.2991/978-94-6463-457-0_10
ID  - Tursinawati2024
ER  -