The bioinformatics analysis of hepatitis C virus E2 protein

DOI

10.2991/iske.2007.131How to use a DOI?

Keywords

Hepatitis C Virus,bioinformatics,E2 protein,epitopes,conservative sites

Abstract

By the methods of bioinformatics, the sequences of HCV E2 protein from all the genotypes are studied on the variation and the B-cell epitopes. We find that even in the HVR1 and HVR2 regions, there are also some conservative sites, such as T2, G6, G23, and Q26, all of which belong to polar R-base amino acids without charge, and can lost proton to conform hydrogen bond. Meanwhile, we find the conservative amino acids locate on the surface of E2 protein, make up of ?-turn and B-cell epitopes. This will contribute to prompt the development of HCV vaccine.

Copyright

© 2007, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Tailin Guo
PY  - 2007/10
DA  - 2007/10
TI  - The bioinformatics analysis of hepatitis C virus E2 protein
BT  - Proceedings of the 2007 International Conference on Intelligent Systems and Knowledge Engineering (ISKE 2007)
PB  - Atlantis Press
SP  - 764
EP  - 769
SN  - 1951-6851
UR  - https://doi.org/10.2991/iske.2007.131
DO  - 10.2991/iske.2007.131
ID  - Guo2007/10
ER  -