Effects of Excess or Insufficient Energy on Immune System of Mice
- 10.2991/978-2-494069-31-2_61How to use a DOI?
- diet restriction; obesity; excess energy; immunity
Nowadays, people have found that excessive or too little energy intake has a great impact on the immune system. Excess energy may lead to weakened immunity, making obese patients more prone to chronic inflammation and tumors. However, the specific molecular mechanism of excess energy acting on the immune system is still not clear. There are also differences in the total impact of too little energy on the human immune system. Therefore, by summing up various opinions and drawing on the research results of a large number of papers, this paper systematically summarizes the impact of energy on the immune system in order to let others have a more comprehensive and profound understanding of the progress in related fields. Through the research, the paper finds that energy deficiency can affect the properties of immune organs and especially reduce the weight of the spleen. Obesity and splenomegaly are closely related and have a certain causal relationship. Obese patients can significantly reduce or keep the peripheral blood T cells unchanged, and their impact on immunity is controversial. Dieting has a positive effect on obese patients and a negative effect on normal people. On the one hand, obesity can promote the activation of macrophages and Th1 cells and strengthen the inflammatory response. On the other hand, adipose tissue itself can secrete cytokines such as leptin to cause chronic inflammation. Obesity can inhibit tumor immunity by affecting the tumor microenvironment, leading to tumor formation.
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Cite this article
TY - CONF AU - Yunfei Ji PY - 2022 DA - 2022/12/29 TI - Effects of Excess or Insufficient Energy on Immune System of Mice BT - Proceedings of the 2022 6th International Seminar on Education, Management and Social Sciences (ISEMSS 2022) PB - Atlantis Press SP - 489 EP - 495 SN - 2352-5398 UR - https://doi.org/10.2991/978-2-494069-31-2_61 DO - 10.2991/978-2-494069-31-2_61 ID - Ji2022 ER -