CAR-NK Cell Therapy: A Promising Alternative to CAR-T Cell Therapy
- 10.2991/978-2-494069-31-2_48How to use a DOI?
- cancer; immunology; chimeric antigen receptor; NK cells
Cancer is one of the deadliest diseases and has long been a leading cause of death. Although the newly introduced chimeric antigen receptors-engineered T cell (CAR-T cell) therapy has been an efficient method to kill cancer cells and inhibit metastasis, its high cytotoxicity, long time to develop, and high cost due to its patient-specific nature suggest that a new treatment is needed. In recent years, researchers have been paying increasing interest in implementing CAR on natural killer cells (NK cells), making them CAR-NK cells similarly to making CAR-T cells. This paper focuses on the process of CAR-NK cell therapy and the extent to which it excels over CAR-T therapy. From several published research and data, it can be concluded that CAR-NK therapy cell is a promising alternative to CAR-T cell therapy as it offers various key advantages including better safety, production convenience, and tumor targeting efficacy. However, challenges such as low cell persistence and transduction efficiency still need to be resolved by further studies and improvements.
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Cite this article
TY - CONF AU - Jinqiao Hu PY - 2022 DA - 2022/12/29 TI - CAR-NK Cell Therapy: A Promising Alternative to CAR-T Cell Therapy BT - Proceedings of the 2022 6th International Seminar on Education, Management and Social Sciences (ISEMSS 2022) PB - Atlantis Press SP - 372 EP - 381 SN - 2352-5398 UR - https://doi.org/10.2991/978-2-494069-31-2_48 DO - 10.2991/978-2-494069-31-2_48 ID - Hu2022 ER -