The Effect of Glycosaminoglycan from Urechis unicinctus on the Protein C system and Relevant Factors Expression of HUVECs

DOI

10.2991/isci-15.2015.82How to use a DOI?

Keywords

Urechis unicinctus; Glycosaminoglycan; Protein C system; Umbilical vein endothelial cells; Gene expression

Abstract

The influence of glycosaminoglycan from Urechis unicinctus on the protein C system and relevant factors expression of human umbilical vein endothelial cells (HUVECs) were studied with enzyme linked immunosorbent and reverse transcript-polymerase chain reaction (RT-PCR). Results indicated that: glycosaminoglycan could significantly decrease content of activated protein C, activated protein S in blood of rats (P<0.05, P<0.01), significantly elevated content of activated protein C inhibitor(P<0.05, P<0.01), slightly increase the thrombomodulin level. Glycosaminoglycan could significantly reduce the expression of tissue factor gene, promote the expression of tissue factor pathway inhibitor and thrombomodulin gene (P<0.01).

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ping Liu
AU  - Qingman Cui
AU  - Wanying Wang
AU  - Chunying Yuan
PY  - 2015/01
DA  - 2015/01
TI  - The Effect of Glycosaminoglycan from Urechis unicinctus on the Protein C system and Relevant Factors Expression of HUVECs
BT  - Proceedings of the 2015 International Symposium on Computers & Informatics
PB  - Atlantis Press
SP  - 617
EP  - 624
SN  - 2352-538X
UR  - https://doi.org/10.2991/isci-15.2015.82
DO  - 10.2991/isci-15.2015.82
ID  - Liu2015/01
ER  -