Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations Via Schiff ’s Base Reaction
- DOI
- 10.2991/ahsr.k.211012.011How to use a DOI?
- Keywords
- spectrophotometric determination, metoclopramide, 2-hydroxy-1-naphthaldehyde, Schiff base
- Abstract
A method for determining metoclopramide (MCPD) as pure and in formulations has been suggested. The proposed method is characterized by simplicity, speed, and sensitivity. It is a spectrophotometric method based on the condensation interaction between the primary aromatic amine group in metoclopramide and the carbonyl group of aromatic aldehyde in the chromogenic reagent 2-hydroxy-1-naphthaldehyde (2HND) in an acidic medium of H2SO4 and absolute ethanol as the optimal medium. The Schiff base product of the condensation reaction is a yellow-colored product, which exhibits the highest absorption intensity at the wavelength of 447 nm. The proposed method is obeyed to Beer’s law in the concentration range of 2 to 20 μg/ml, with a determination coefficient of 0.9960, molar absorption of 1.15 x 104 l/ mol.cm, while Sandell’s sensitivity index has a significance of 0.0306 μg/ cm2.The method was estimated statistically by calculating the percentage of relative error (RE%) can express the accuracy and the percentage of relative standard deviation (RSD%) can express precession. The method has been successfully applied in the determination of metoclopramide in pharmaceutical preparations in the form of tablets and injections.
- Copyright
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Rabee Ali AU - Nabeel Othman PY - 2021 DA - 2021/10/12 TI - Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations Via Schiff ’s Base Reaction BT - Proceedings of the 1st International Ninevah Conference on Medical Sciences (INCMS 2021) PB - Atlantis Press SP - 63 EP - 69 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211012.011 DO - 10.2991/ahsr.k.211012.011 ID - Ali2021 ER -