The Beneficial Effect of Glutathione in Protection of the Central Nerves System from Damage Induced by D-galactose
- DOI
- 10.2991/ahsr.k.211012.012How to use a DOI?
- Keywords
- D-galactose, Glutathione, beta amyloid, Acetylcholinesterase, aging
- Abstract
Glutathione is a tripeptide that protect cells from oxidative damage and it is also an important regulator of redox signaling, plays a role in xenobiotic detoxification, and influences cell proliferation, apoptosis, immunological function, and fibrogenesis. The aim of this study is Study the effect of antioxidant Glutathione to minimize the aging effect of d-galactose on central nerves system. And its effect on the antioxidants enzyme. Twenty-four female rat were used in the experiment. The rats divided to four group each group with six rats. And were given a daily injection of 100 mg/kg (of body weight) intraperitoneally for six weeks. Glutathione, D-Galactose, D-Galactose and Glutathione and normal saline (as same as volume used in the other group), after the end of the six week the rats were sacrifice and serum samples were taken. The study showed that use of glutathione as antioxidant reduced the constriction of beta amyloid in the body when compared to the group that was injected only with D-galactose at level of (p-value <0.01), The main value of beta amyloid was (12.7±3.33, 26.78±4.47, 8.55±1.37, 22.31±1.95) for groups Control, d-gal GSH and GSH+D-gal respectively., in another hand It was noted that Acetylcholinesterase has a significant increase in D- galactose group when compared to other group at level of (p-value >0.05), the main value of Acetylcholinesterase was (6.17±0.77, 16.12±4.19, 5.21±0.75, 9.15±3.55) for groups Control, GSH, d-gal and GSH+D-gal respectively. Glutathione peroxidase show that significant increase in D- galactose group (G3) at level of (p-value <0.01) when compared to the other group, and there is no significant change between control and GSH at level of (p-value <0.01), the main value was (30.69±6.98, 37.22±3.09, 28.42±0.75, 33.22±1.24) for groups Control, d-gal, GSH and GSH+D-gal respectively. Melanoaldihide showed that GSH group has significant decrease at level of (p-value <0.05) when compared to the other groups. The main value for groups was (35.98 ± 0.67, 39.05± 2.39, 31.7± 1.47, 36.51 ±1.27) for groups Control, GSH, d-gal and GSH+D-gal respectively.
- Copyright
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Sadiq Safaa Mahdi AU - Wefak Albazi AU - Muna hussain Al-Aameli PY - 2021 DA - 2021/10/12 TI - The Beneficial Effect of Glutathione in Protection of the Central Nerves System from Damage Induced by D-galactose BT - Proceedings of the 1st International Ninevah Conference on Medical Sciences (INCMS 2021) PB - Atlantis Press SP - 70 EP - 74 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211012.012 DO - 10.2991/ahsr.k.211012.012 ID - Mahdi2021 ER -