Preparation and Dissolution of Solid Dispersions of Sanguis Draconis
Chang Min Xing, Xue Ming Wang, Kuan Cao, Hui Chao Liu, Yong Liu, Nan Li
Chang Min Xing
Available Online March 2017.
- https://doi.org/10.2991/ifmca-16.2017.141How to use a DOI?
- sanguis draconis, solid dispersions, dissolubility, polyethylene glycol, polyvinyl pyrrolidone
- Sanguis draconis is a precious traditional Chinese medicine, but it is not soluble in water, and it is difficult to use in type of injection. Sanguis draconis has a low bioavailability, because the coarse particles of draconis can be absorbed very little. In present research, solid dispersions of sanguis draconis were prepared using solvent method and melting methods with PEG-6000 and PVPK30 as carriers. The dissolubility in vitro was determined by UV method. Results showed that higher carrier ratio led to faster drug dissolution. The dissolubility of solid dispersions with PVPK30 was faster than that with PEG-6000. The solid dispersions of sanguis draconis can improve its dissolution obviously, which promotes the absorption and bioavailability of this medicine.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Chang Min Xing AU - Xue Ming Wang AU - Kuan Cao AU - Hui Chao Liu AU - Yong Liu AU - Nan Li PY - 2017/03 DA - 2017/03 TI - Preparation and Dissolution of Solid Dispersions of Sanguis Draconis BT - Proceedings of the 2016 International Forum on Mechanical, Control and Automation (IFMCA 2016) PB - Atlantis Press SP - 900 EP - 903 SN - 2352-5401 UR - https://doi.org/10.2991/ifmca-16.2017.141 DO - https://doi.org/10.2991/ifmca-16.2017.141 ID - Xing2017/03 ER -