Application of silk fibroin/ chitosan wound dressing to rat skin regeneration

DOI

10.2991/ifeesm-15.2015.40How to use a DOI?

Keywords

silk fibroin; chitosan; wound dressing; skin regeneration

Abstract

In this study, a new bi-layered silk fibroin (SF)/ chitosan (CS) wound dressing was investigated. The morphology, cytocompatibility and effect on open wound healing in rats were studied. The results show that the SF/CS wound dressing has homogeneous porous structure and support the attachment and proliferation of L929 mouse fibroblasts. Furthermore, it proves that, comparing with the clinically used wound dressing, the SF/CS wound dressing promote skin healing in full-thickness wounds, and show greater extent in wound size reduction, epitheliazation and collagen formation. The empirical results in this study indicate that SF/CS wound dressing maybe a good candidate for skin regeneration.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhi-hua Lu
AU  - Yu-dong Ma
AU  - Dong-mei Zhao
AU  - Hong-yao Xu
PY  - 2015/09
DA  - 2015/09
TI  - Application of silk fibroin/ chitosan wound dressing to rat skin regeneration
BT  - Proceedings of the 2015 International Forum on Energy, Environment Science and Materials
PB  - Atlantis Press
SP  - 205
EP  - 208
SN  - 2352-5401
UR  - https://doi.org/10.2991/ifeesm-15.2015.40
DO  - 10.2991/ifeesm-15.2015.40
ID  - Lu2015/09
ER  -