Efficacy of Jatropha Sap (Jatropha curcas L.) Cream on Epithelialization Phase of Cutaneous Wound Healing in Mice Using Masson Trichome Staining

DOI

10.2991/absr.k.210420.014How to use a DOI?

Keywords

Jatropha’s sap cream, cutaneous wound, angiogenesis, collagen density

Abstract

This study aims to determine the efficacy of 10% Jatropha curcas Linn. cream on the epithelialization phase of cutaneous wound healing in mice (Mus musculus) using Masson Trichrome staining. This study used nine male mice, aged 2-3 months old with 2 cm incision was made on the back. The mice were divided into three treatment groups with three replications. Treatment I was applied with cream base (P1), treatment II was applied with 10% Jatropha’s sap cream (P2), and treatment III was applied with sulfadiazine (P3). The wound was treated twice a day for seven days. The observed parameters were collagen density, fibroblast formation and angiogenesis in each treatment group. The data were analyzed by ANOVA followed by Duncan test if there were differences between the treatment groups. The results showed that collagen density in P1, P2, and P3 were 1.58 ± 0.00, 2.04 ± 0.14, and 1.95 ± 0.14, respectively, indicating a very significant difference (p <0.01). Fibroblasts formation did not differ (p> 0.05) among treatments with the values in P1, P2, and P3 were 2.04 ± 0.14, 1.56 ± 0.32, 1.95 ± 0.14, respectively. Angiogenesis in P1, P2, and P3 were 1.46 ± 0.21, 1.87 ± 0.00, 1.46 ± 0.21, respectively, which had a significant effect (p <0.05). It is concluded that application of 10% Jatropha cream for seven days is effective in increasing collagen density and angiogenesis that accelerate the cutaneous wound healing in mice.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - M. Nur Salim
AU  - Ummu Balqis
AU  - Rahma Erlis
AU  - Dian Masyitha
AU  - Erdiansyah Rahmi
AU  - Abdul Harris
PY  - 2021
DA  - 2021/04/21
TI  - Efficacy of Jatropha Sap (Jatropha curcas L.) Cream on Epithelialization Phase of Cutaneous Wound Healing in Mice Using Masson Trichome Staining
BT  - Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)
PB  - Atlantis Press
SP  - 60
EP  - 64
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.210420.014
DO  - 10.2991/absr.k.210420.014
ID  - Salim2021
ER  -