Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice

DOI

10.2991/icpsuas-17.2018.20How to use a DOI?

Keywords

alpha-mangostin, blood urea nitrogen, diabetic mice, plasma creatinine, renal proximal tubular of kidney

Abstract

This research was aimed to investigate that alpha-mangostin compound derived from mangosteen pericarp able to reduce blood urea nitrogen (BUN), plasma creatinine, also for amelioration of renal proximal tubular of kidney in diabetic mice. In vivo of antioxidant test was conducted by using strain male BALB/c mice. Mice were divided into two groups; normal control (KN) and streptozotocin-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-dose of 30 mg/kg bw injected for five consecutive days. Diabetic mice were separated again into three subgroups; diabetic control (KD), diabetic mice treated with Metformin HCl (KM), and diabetic mice treated with alpha-mangostin. Alpha-mangostin treatment group was differentiated based on dose given; P1 (2 mg/kg bw), P2 (4 mg/Kg bw), and P3 (8 mg/Kg bw). Before and after STZ injection, body weight and fasting blood glucose were measured. Body weight and fasting blood glucose were measured at 1st, 7th and 14th day of alpha-mangostin treatment. Treatment was given for 14 days. At 15th day, BUN and plasma creatinine were measured using Pentra C 200 Reader. Result showed that alpha-mangostin administration was able to reduce BUN, plasma creatinine, and ameliorates renal proximal tubular of kidney in diabetic mice significantly.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Saikhu Akhmad Husen
AU  - Firas Khaleyla
AU  - Arif Nur Muhammad Ansori
AU  - Raden Joko Kuncoroningrat Susilo
AU  - Dwi Winarni
PY  - 2017/08
DA  - 2017/08
TI  - Antioxidant Activity Assay of Alpha-mangostin for Amelioration of Kidney Structure and Function in Diabetic Mice
BT  - Proceedings of the 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change Agreement to Meet Sustainable Development Goals" (ICPSUAS 2017)
PB  - Atlantis Press
SP  - 84
EP  - 88
SN  - 2352-5398
UR  - https://doi.org/10.2991/icpsuas-17.2018.20
DO  - 10.2991/icpsuas-17.2018.20
ID  - AkhmadHusen2017/08
ER  -