The Combined Effect of Extract Seaweed and DHP on Placental Malaria

DOI

10.2991/assehr.k.210421.065How to use a DOI?

Keywords

Parasitemia, cytoadherence, Low birth weight, Eucheuma cottonii, Dinydroartemisinin

Abstract

Placental malaria is characterized by infected erythrocyte cytoadherence and TNF-α expression in the intervillous placental space. This can interfere with the transport of nutrients, which can affect the growth of the fetus. Seaweed (Eucheuma cottonii) is a typical Indonesian plant containing polysaccharide sulfate that has an antimalarial function. The purpose of this study was to investigate the effect of seaweed (Eucheuma cottonii) combined with DHP in the degree of parasitemia, cytoadherence, TNF-α, and fetal growth of mice in Plasmodium berghei infection. Mice pregnant 24 days on day 9 post-mating in Plasmodium berghei infection then divided into 4 groups: group A (without treatment), group B (DHP 0,0364 mg / gr BB), group C (seaweed 0,5 mg / grBB), group D (DHP 0,0364 mg / gr BB and seaweed 1 mg / grBB). Analysis using Structural Equation Modeling (SEM) (ttable ≥ 1.96) showed the Group (A), causing a high degree of parasitemia, TNF-α expression, cytoadherence, and low birth weight. Group (B), decreased degree of parasitemia, but cytoadherence, TNF-α expression, and low birth weight remained high. Group (C), decreased degree of parasitemia, cytoadherence, TNF-α expression and prevent low birth weight. Group (D), decreased degree of parasitemia, cytoadherence, TNF-α expression and prevent low birth weight. Eucheuma cottonii single therapy and combination therapy Eucheuma cottonii with DHP can prevent parasitemia, cytoadherence, TNF-α, and low birth weight while single DHP therapy may decrease the degree of cytoadherence parasitemia but cytoadherence, TNF-α expression, and low birth weight but high.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zainabur Rahmah
AU  - Nurfianti Indriana
AU  - Lina Fitria Astari
AU  - Alvi Milliana
AU  - Sutikno
PY  - 2021
DA  - 2021/04/22
TI  - The Combined Effect of Extract Seaweed and DHP on Placental Malaria
BT  - Proceedings of the International Conference on Engineering, Technology and Social Science (ICONETOS 2020)
PB  - Atlantis Press
SP  - 452
EP  - 458
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.210421.065
DO  - 10.2991/assehr.k.210421.065
ID  - Rahmah2021
ER  -