Comparison of Histology of The Kidneys of Rats Exposed To Cigarette Smoke After Administration of Ethanol Extract Methanol and N-Hexane Rhizophora apiculata Bark

DOI

10.2991/978-94-6463-604-8_16How to use a DOI?

Keywords

Cigarette Smoke; Rhizophora apiculata; renal histology

Abstract

Rhizophora apiculata is a plant species that yields medicinal raw materials. This research compares the protective effects of ethanol, methanol, and n-hexane extracts of Rhizophora apiculata mangrove bark on the kidneys of rats exposed to cigarette smoke. The study used a post-test-only control group design on 30 rats divided into six groups for 30 days. All groups were exposed to 24 cigarette smokes/day except for the Control group (C); the negative control group (NC) only received exposure to cigarette smoke. The positive control group (PC) was given vitamin C 9 mg/kgBW/day, and the E, M, and N groups were each given ethanol, methanol, and n-hexane extracts of 56.55 mg/kgBW/day. On the 31st day terminated preparations and scoring of renal histology were carried out. The data were analyzed using the Shapiro-Wilk normality test, then the Kruskal-Wallis non-parametric test, and finally the Mann-Whitney post-hoc test. The average kidney damage score for C, NC, PC, E, M, and N was 0.24, 3.48, 2.6, 2.4, 2.44, and 2.4, respectively. There was a significant difference (p < 0.05) between PC, E, M, and N versus NC. The PC, E, M, and N damage scores showed no significant difference (p > 0.05). Ethanol, methanol, and n-hexane extracts of Rhizophora apiculata mangrove bark at a dose of 56.55 mg/kgBW/day protect the kidneys from cigarette smoke exposure. The three extracts have the same effect as vitamin C at 9 mg/kgBW/day.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Syazili Mustofa
AU  - Muhammad Yusha Akbar
PY  - 2024
DA  - 2024/12/19
TI  - Comparison of Histology of The Kidneys of Rats Exposed To Cigarette Smoke After Administration of Ethanol Extract Methanol and N-Hexane Rhizophora apiculata Bark
BT  - Proceedings of the International Conference on Medical Science and Health (ICOMESH 2024)
PB  - Atlantis Press
SP  - 183
EP  - 189
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-604-8_16
DO  - 10.2991/978-94-6463-604-8_16
ID  - Mustofa2024
ER  -