Proceedings of the 4th International Conference on Mechatronics, Materials, Chemistry and Computer Engineering 2015

Study on Osteopontin and Its Clinical Application to Ovarian Cancer

Authors
Lihong Bao
Corresponding Author
Lihong Bao
Available Online December 2015.
DOI
https://doi.org/10.2991/icmmcce-15.2015.380How to use a DOI?
Keywords
Osteopontin (OPN), Ovarian Cancer, Clinical Application
Abstract
Osteopontin (OPN) is a kind of phosphorylated acidic glycoprotein, human beings' osteoclasts, macrophages, T cells, and vascular smooth muscle cells can secrete OPN, the gene is located on chromosome 4q13. OPN has a function of adhesion to protein, which can be combined with CD44, integrin v 3 and v 5, OPN is also involved in bone remodeling, the formation of new blood vessel and the reflection of inflammation. OPN can play the synergistic function in tumor metastasis. In this paper, it takes the introduction of biological function of OPN. As for the aspect of early diagnosis of ovarian cancer and prognosis monitoring, it can be used as the supplement of CA125 and markers of other cytokines.
Open Access
This is an open access article distributed under the CC BY-NC license.

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TY  - CONF
AU  - Lihong Bao
PY  - 2015/12
DA  - 2015/12
TI  - Study on Osteopontin and Its Clinical Application to Ovarian Cancer
BT  - Proceedings of the 4th International Conference on Mechatronics, Materials, Chemistry and Computer Engineering 2015
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/icmmcce-15.2015.380
DO  - https://doi.org/10.2991/icmmcce-15.2015.380
ID  - Bao2015/12
ER  -