Role of Quercetin on inhibiting TGF-beta1 and TNF-alpha in Lung of Rats with Silicosis

DOI

10.2991/icmaee-14.2014.11How to use a DOI?

Keywords

quercetin, silicosis fibrosis, TGF-beta1, TNF-alpha

Abstract

Silicosis, characterized by many cytokines expression, especially TNF-alpha and TGF-beta1, is the most prevalent occupational disease world-wide. Here we examined whether quercetin can regulate expressions of TGF-beta1 and TNF-alpha in lung of rats with silicosis. Totally 75 male Wistar rats, were randomly divided into three groups: group control, group model and group quercetin, (n=25). SiO2 powders were douched in the trachea of rat to make the silicotic model. TGF-beta1 and TNF-alpha were measured by immunohistochemica and ELISA. The results revealed that the contents of TNF-alpha and TGF-beta1 in group model on all the time points were higher than the others, quercetin decreased the expressions of TNF-alpha and TGF-beta1. The current study results further suggest that quercetin may have therapeutic efficacy in treatment of silicosis of the lung.

Copyright

© 2014, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Haibing Peng
PY  - 2014/03
DA  - 2014/03
TI  - Role of Quercetin on inhibiting TGF-beta1 and TNF-alpha in Lung of Rats with Silicosis
BT  - Proceedings of the International Conference on Material and Environmental Engineering (ICMAEE 2014)
PB  - Atlantis Press
SP  - 40
EP  - 42
SN  - 1951-6851
UR  - https://doi.org/10.2991/icmaee-14.2014.11
DO  - 10.2991/icmaee-14.2014.11
ID  - Peng2014/03
ER  -