Influence of Enos Expression Regulators on Changes in the Endothelium Function Under the Intoxication Syndrome

DOI

10.2991/ahsr.k.201001.024How to use a DOI?

Keywords

nickel, lipid peroxidation, AOS, nitric oxide, endothelial dysfunction

Abstract

The study was conducted on a model of endothelial dysfunction caused by intoxication with nickel chloride and an eNOS inhibitor – L-NAME. The results showed a significant increase in oxidants and their inhibitory effect on the development of nitric oxide (NO) – a biochemical marker of the endothelial dysfunction. When introducing nickel and modified L-arginine, the internal molecular structure of endothelial NO synthase (eNOS) and the ability of the enzyme to produce nitric oxide and active oxygen metabolites (AMA) is violated. L-arginine stimulates the expression of eNOS, the development of nitric oxide and inhibits lipoperoxidation. This experimental method is relevant, because only fundamental knowledge about the mechanisms of development of endothelial dysfunction will allow us to develop a predictive approach for the prevention of negative effects.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - S.G. Dzugkoev
AU  - F.S. Dzugkoeva
AU  - O.I. Margieva
AU  - O.Yu. Garmash
AU  - I.V. Mozhaeva
AU  - A.I. Tedtoeva
PY  - 2020
DA  - 2020/10/03
TI  - Influence of Enos Expression Regulators on Changes in the Endothelium Function Under the Intoxication Syndrome
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 115
EP  - 118
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.024
DO  - 10.2991/ahsr.k.201001.024
ID  - Dzugkoev2020
ER  -