Cytogenetic Effects of Cytostatics and Their Relationship With p53 Gene Polymorphism

DOI

10.2991/ahsr.k.201001.023How to use a DOI?

Keywords

karyological parameters, chemotherapy, cytostatics, p53 gene polymorphism, breast cancer

Abstract

The karyological parameters of buccal epithelial cells were studied as markers of the effects of chemotherapy drugs (doxorubicin with cyclophosphamide (DC) and paclitaxel) in 68 patients with diagnosed breast cancer taking into account p53 gene polymorphism (rs17884159). It was shown that paclitaxel has a stronger mutagenic effect compared with the regimen of DC: the share of cells with micronuclei and protrusions and binuclear cells increases. Evaluation of the karyological parameters of buccal epithelial cells and the significance of the minor p53 gene T allele (26 + 4486C> T) for tumor development in patients with breast cancer shows that chemotherapy is accompanied by integral processes that enhance nuclear destruction processes and cause the genome instability. It is shown that the indicators of karyological analysis can be biomarkers of the mutagenic effect of therapeutic treatment using cytostatics.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Z.I. Bisultanova
AU  - P.M. Dzhambetova
AU  - M.M. Atsaeva
AU  - L.M. Dzhambetova
AU  - Kh.Sa. Musaeva
PY  - 2020
DA  - 2020/10/03
TI  - Cytogenetic Effects of Cytostatics and Their Relationship With p53 Gene Polymorphism
BT  - Proceedings of the International Conference “Health and wellbeing in modern society” (ICHW 2020)
PB  - Atlantis Press
SP  - 109
EP  - 114
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.201001.023
DO  - 10.2991/ahsr.k.201001.023
ID  - Bisultanova2020
ER  -