In Silico Analysis of the Inhibitory Potential of Zingiber Officinale Roscoe Compounds Against SARS-CoV-2

DOI

10.2991/978-94-6463-112-8_34How to use a DOI?

Keywords

Z. officinale Roscoe; molecular docking; inhibitory activity SAR-CoV-2

Abstract

In traditional medicine, Z. officinale has been known and used for centuries. However, with the current ongoing COVID-19 pandemic, Z. officinale is increasingly being used to treat symptoms of COVID-19 and increase overall immunity. The presence of multiple phytochemicals contained in Z. officinale has been widely reported. In this study, we tried to observe the inhibitory activity of the chemical constituents in Z. officinale against SAR-CoV-2. We used the main protease COVID-19 receptor which obtained from a protein data bank coded PDB ID 6LU7, to tether the active compound within Z. officinale. Protease is a protein that can represent a target for inhibition of viral replication or transcription. Proteases are widely used in the treatment of viruses since viral replication generally occurs with the aid of proteases. Currently proteases are widely used in the development of antiviral therapy and as a target protein. Evaluation of the inhibitory effect of the active compound in Z. officinale on the protein was performed. The molecular docking results of the 60 chemical compounds contained within Z. officinale showed that there were 2 chemical compounds in Z. officinale, Zingeberene and Lariciresinol that had the highest activity against the protein. Overall, fifteen of the 60 analyze by the molecular docking test showed the ability to inhibit protease protein. The molecular docking simulation showed that Z. officinale has activity against the SARS-CoV-2 PDB 6LU7 protein. The biological activity of potential active compounds in Z. officinale against SARS-CoV-2 and its associated mechanisms of action must be investigated further.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Teni Ernawati
PY  - 2023
DA  - 2023/03/01
TI  - In Silico Analysis of the Inhibitory Potential of Zingiber Officinale Roscoe Compounds Against SARS-CoV-2
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 360
EP  - 373
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_34
DO  - 10.2991/978-94-6463-112-8_34
ID  - Ernawati2023
ER  -