Membrane of Usnic Acid in Solid Dispersion and Effectiveness in Burn Healing

Lili Fitriani; Bella Fista; Friardi Ismed; Erizal Zaini

doi:10.2991/ahsr.k.211105.047

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Membrane of Usnic Acid in Solid Dispersion and Effectiveness in Burn Healing

Authors

Lili Fitriani¹^{, *}, Bella Fista¹, Friardi Ismed², Erizal Zaini¹

¹Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, 25163

²Laboratory of Biota Sumatera and Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, 25163

^*Corresponding author. Email: lilifitriani@phar.unand.ac.id

Corresponding Author

Lili Fitriani

Available Online 17 November 2021.

DOI: 10.2991/ahsr.k.211105.047 How to use a DOI?
Keywords: usnic acid; solid dispersion; membrane; burn healing
Abstract: Usnic acid, a yellow crystalline of secondary metabolite of Usnea sp., has been known for its tremendous pharmacological activities including antibacterial and anti-inflammatory activities. The aim of this study was to prepare membrane containing usnic acid and evaluate its effectiveness for burns healing. Prior to the preparation of membrane, usnic acid was modified into solid dispersion (SD) system by freeze drying method using PVP K-30 (ratio usnic acid- PVP: 1:2 w/w). Then, usnic acid in solid dispersion with equivalent concentration of usnic acid at 0.5% (F1), 1% (F2), and 2% (F3) were formulated into membrane using poly-vinyl alcohol (PVA), glycerin and distilled water. The membranes were evaluated for the physical and mechanical properties including: appearance, thickness, tensile strength, percent of elongation, and Young’s modulus. The effectiveness of burn healing activity was done on male white rabbits by creating superficial burns and evaluated the diameter of wound for 21 days. The appearance of each membrane was transparent but the color was different due to the concentration of usnic acid. The thickness of each membrane was less than 0.1 mm. F2 had the highest tensile strength, percent of elongation, and Young’s modulus. Meanwhile, F3 showed a better result in burn healing compared to F2 and F1. The higher concentration of usnic acid solid dispersion in membrane increased effectiveness of burn healing significantly (p<0.05).
Copyright: © 2021 The Authors. Published by Atlantis Press International B.V.
Open Access: This is an open access article under the CC BY-NC license.

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Volume Title: Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
Series: Advances in Health Sciences Research
Publication Date: 17 November 2021
ISBN: 10.2991/ahsr.k.211105.047
ISSN: 2468-5739
DOI: 10.2991/ahsr.k.211105.047 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC license.

Cite this article

ris enw bib

TY  - CONF
AU  - Lili Fitriani
AU  - Bella Fista
AU  - Friardi Ismed
AU  - Erizal Zaini
PY  - 2021
DA  - 2021/11/17
TI  - Membrane of Usnic Acid in Solid Dispersion and Effectiveness in Burn Healing
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 323
EP  - 329
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.047
DO  - 10.2991/ahsr.k.211105.047
ID  - Fitriani2021
ER  -

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