Proceedings of the 5th International Conference on Chemical Investigation and Utilization of Natural Resource (ICCIUNR-2021)

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Antioxidant and Antihypertensive Activity of Collagen and Elastin Hydrolysate at Different Molecular Weights

Authors
Bayarjargal Munkhuu, Lkhagvamaa Erdene, Zolzaya Bayarsukh, Enkh-Ariun Altantulga, Oyuntuya Baltsukh, Gan-Erdene Tudev, Ariun Narmandakh
Corresponding Author
Bayarjargal Munkhuu
Available Online 5 October 2021.
DOI
10.2991/ahcps.k.211004.004How to use a DOI?
Keywords
Raw-hide, Ligamentum nuchae, Hydrolysate, Ultrafiltration, Peptides, Angiotensin-converting enzyme inhibitor, Antioxidant activity
Abstract

The angiotensin-converting enzyme (ACE) inhibitory activity and antioxidant property of collagen and elastin hydrolysates, and their peptide fractions (< 5 kDa, 5-10 kDa, 10-100 kDa) were compared. The bovine raw-hide and paddywhack (Ligamentum nuchae) were used for the preparation of collagen and elastin hydrolysates, respectively. Unfractionated collagen and elastin hydrolysates (4 mg/mL) could reduce ACE activity by 61% and 58%. As a result of fractionation, ACE inhibitory activity of collagen hydrolysate was increased up to 85%, while this effect was not observed on elastin hydrolysate. Elastin hydrolysate showed intense radical scavenging abilities through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid (ABTS) assay. The collagen hydrolysate obtained from the bovine rawhide has more perspective for the bioactive food additive having ACEI activity in comparison with the elastin hydrolysate.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 5th International Conference on Chemical Investigation and Utilization of Natural Resource (ICCIUNR-2021)
Series
Atlantis Highlights in Chemistry and Pharmaceutical Sciences
Publication Date
5 October 2021
ISBN
978-94-6239-436-0
ISSN
2590-3195
DOI
10.2991/ahcps.k.211004.004How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Bayarjargal Munkhuu
AU  - Lkhagvamaa Erdene
AU  - Zolzaya Bayarsukh
AU  - Enkh-Ariun Altantulga
AU  - Oyuntuya Baltsukh
AU  - Gan-Erdene Tudev
AU  - Ariun Narmandakh
PY  - 2021
DA  - 2021/10/05
TI  - Antioxidant and Antihypertensive Activity of Collagen and Elastin Hydrolysate at Different Molecular Weights
BT  - Proceedings of the 5th International Conference on Chemical Investigation and Utilization of Natural Resource (ICCIUNR-2021)
PB  - Atlantis Press
SP  - 21
EP  - 27
SN  - 2590-3195
UR  - https://doi.org/10.2991/ahcps.k.211004.004
DO  - 10.2991/ahcps.k.211004.004
ID  - Munkhuu2021
ER  -