Proceedings of the 1st International Conference on Community Health (ICCH 2019)

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Potential of Pharmacodynamic Interaction for Hospital Patients with Stroke: A Retrospective Study

Authors
Ikhwan Yuda Kusuma, Desy Nawangsari, Linda Sukiatno, Yuyun Pujiarti
Corresponding Author
Ikhwan Yuda Kusuma
Available Online 10 February 2020.
DOI
10.2991/ahsr.k.200204.007How to use a DOI?
Keywords
stroke, pharmacodynamics, drug interactions, hospital
Abstract

Stroke is a functional brain disorder in the form of nerve paralysis (deficit neurologic) due to obstruction of blood flow to the brain. Based on the Basic health research (Riskesdas) in 2018, the prevalence of stroke in Indonesia increased from 7% (2013) to 10.9% (2018) so it is necessary to optimize therapy for patients. Stroke treatment therapy, in general, uses two or more drugs (polypharmacy) so that this is able to increase the potential for drug interactions in patients either pharmacokinetic or pharmacodynamic. This study was aimed to investigate the potential for pharmacodynamic drug interactions and management of drug interaction events on stroke patients with polypharmacy therapy in hospital. The method of this study was retrospective observational. Data were analyzed descriptively using Stockley’s Drug Interaction, Drug Interaction Facts, www.drugs.com database, and Medscape Drug Interactions Checker. The sampling technique employed in this study was total sampling method. The findings revealed that potential drug interactions on stroke patients in the hospital were 61.40% (n = 27 samples). The most mechanism pattern was pharmacodynamic interaction between aspirin-amlodipine (13.8%) and the most severity was in moderate level (77.78%).

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 1st International Conference on Community Health (ICCH 2019)
Series
Advances in Health Sciences Research
Publication Date
10 February 2020
ISBN
10.2991/ahsr.k.200204.007
ISSN
2468-5739
DOI
10.2991/ahsr.k.200204.007How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Ikhwan Yuda Kusuma
AU  - Desy Nawangsari
AU  - Linda Sukiatno
AU  - Yuyun Pujiarti
PY  - 2020
DA  - 2020/02/10
TI  - Potential of Pharmacodynamic Interaction for Hospital Patients with Stroke: A Retrospective Study
BT  - Proceedings of the 1st International Conference on Community Health (ICCH 2019)
PB  - Atlantis Press
SP  - 26
EP  - 29
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200204.007
DO  - 10.2991/ahsr.k.200204.007
ID  - Kusuma2020
ER  -