Scabies Vaccine as a New Breakthrough for the Challenge of Acaricides Resistance

DOI

10.2991/absr.k.200513.036How to use a DOI?

Keywords

disease, immunodiagnostic, immunotherapy, scabies, resistance

Abstract

Scabies is first recorded as far back as 2500 years ago and considered as an ancient disease. It affects around 300 million people every year around the world, and its prevalence is as high as around 60% in children. Several amount of drugs have been used for the disease treatment, but conventional therapy become resistant throughout the year and it keep increasing. Sarcoptes scabiei mites are able to develop new means to avoid newer therapies. Hence, in order to eradicate them, radical solutions such as vaccination, are required. The treatments currently available for scabies can cause problems due to side effects and maybe the risk of treatment failure. The available coping methods like treating diagnosed individuals are ineffective and impractical. Resistance to mites and consumer rejection of livestock products containing drug residues are aggravating issues. Although there may be potential for immunological control, vaccine development or other immunotherapy modalities may be several decades away. The current therapy has faced some rising serious concerns such as developing resistance to classical scabicides among scabies mites and the ineffectiveness of current treatments associated with scabies (in suppressing skin inflammatory reactions and secondary bacterial infections). Treatment adherence difficulties, and the uncertainty of safety and efficacy in young and elderly, makes necessary to identify new treatments for scabies. Vaccination is the best alternative way because it is safe for the environment and consumers, and potentially more effective and inexpensive.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Aryani Adji
AU  - Laurentius J M Rumokoy
AU  - Christina L Salaki
PY  - 2020
DA  - 2020/05/18
TI  - Scabies Vaccine as a New Breakthrough for the Challenge of Acaricides Resistance
BT  - Proceedings of the International Conference and the 10th Congress of the Entomological Society of Indonesia (ICCESI 2019)
PB  - Atlantis Press
SP  - 208
EP  - 213
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.200513.036
DO  - 10.2991/absr.k.200513.036
ID  - Adji2020
ER  -