Anti-hepatocarcinoma effects of chrysin loaded solid lipid nanoparticle against H22 tumor bearing mice

DOI

10.2991/ic3me-15.2015.197How to use a DOI?

Keywords

solid lipid nanoparticles; Chrysin; Cytotoxicity; Antitumor activity; H22 cells; tumor bearing mice

Abstract

Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Chrysin (Chr), a major symbol ingredient in Chinese Propolis, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Chr-loaded solid lipid nanoparticles (Chr-SLN) composed of Chr, cremophor EL and glyceryl behenate were prepared by high pressure homogenization technique. The in vivo anti-hepatocarcinoma effects of Chr-SLN relative to efficacy of bulk Chr were evaluated. The particle size and zeta potential of Chr-SLN were 479.7 nm and 26.3 mV, respectively. The results showed higher antitumor efficacy against H22 solid tumor bearing mice. These results suggest that the delivery of Chr-SLN is a promising approach for treating tumors.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhiping Wang
AU  - Hua Fan
AU  - Yan Li
AU  - Yifei Wang
PY  - 2015/08
DA  - 2015/08
TI  - Anti-hepatocarcinoma effects of chrysin loaded solid lipid nanoparticle against H22 tumor bearing mice
BT  - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
PB  - Atlantis Press
SP  - 1020
EP  - 1024
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.197
DO  - 10.2991/ic3me-15.2015.197
ID  - Wang2015/08
ER  -